Pricing Availability   Qty
Description: GRK2 inhibitory polypeptide; Gβ/γ antagonist
Purity: ≥95% (HPLC)
Citations (4)

Biological Activity for GRK2i

GRK2i is a GRK2 inhibitory polypeptide that specifically inhibits Gβγ activation of GRK2. Corresponds to the Gβγ-binding domain and acts as a cellular Gβγ antagonist.

Technical Data for GRK2i

M. Wt 3484.08
Formula C153H256N50O41S
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 148505-03-7
PubChem ID 90488863
Smiles [H]N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for GRK2i

Solubility Soluble to 2 mg/ml in water

Product Datasheets for GRK2i

Certificate of Analysis / Product Datasheet
Select another batch:

References for GRK2i

References are publications that support the biological activity of the product.

Koch et al (1994) Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates Gβγ-mediated signaling. J.Biol.Chem. 269 6193 PMID: 8119963

Macrez et al (1997) A βγ dimer derived from G13 transduces the angiotensin AT1 receptor signal to stimulation of Ca2+ channels in rat portal vein myocytes. J.Biol.Chem. 272 23180 PMID: 9287322

Dang et al (2009) Two distinct mechanisms mediate acute μ-opioid receptor desensitization in native neurons. J.Neurosci. 29 3322 PMID: 19279269

If you know of a relevant reference for GRK2i, please let us know.

View Related Products by Product Action

View all Heterotrimeric G-protein GTPase Inhibitors

Keywords: GRK2i, GRK2i supplier, GRK, inhibitory, polypeptide, Gbg, antagonists, Gβγ, Gbetagamma, G, protein, heterotrimeric, Heterotrimeric, G-protein, GTPases, 3594, Tocris Bioscience

4 Citations for GRK2i

Citations are publications that use Tocris products. Selected citations for GRK2i include:

Stott et al (2015) G-protein βγ subunits are positive regulators of Kv7.4 and native vascular Kv7 channel activity. Apoptosis 112 6497 PMID: 25941381

Lutz et al (2021) Gαo is a major determinant of cAMP signaling in the pathophysiology of movement disorders. Cell Rep 34 108718 PMID: 33535037

Kirill A et al (2019) Homeostatic cAMP regulation by the RGS7 complex controls depression-related behaviors. Neuropsychopharmacology 44 642-653 PMID: 30546127

Sierra-Fonseca et al (2014) Nerve growth factor induces neurite outgrowth of PC12 cells by promoting Gβγ-microtubule interaction. BMC Neurosci 15 132 PMID: 25552352

Do you know of a great paper that uses GRK2i from Tocris? Please let us know.

Reviews for GRK2i

There are currently no reviews for this product. Be the first to review GRK2i and earn rewards!

Have you used GRK2i?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review