GR 94800

Discontinued Product

GR 94800 (Cat. No. 1667) has been withdrawn from sale for commercial reasons.
Description: Potent, selective NK2 antagonist
Purity: ≥95% (HPLC)
Literature (2)

Biological Activity for GR 94800

GR 94800 is a potent and selective tachykinin NK2 receptor antagonist (pKB values are 9.6, 6.4 and 6.0 for NK2, NK1 and NK3 receptors respectively). Active in vivo.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data for GR 94800

M. Wt 904.08
Formula C49H61N9O8
Sequence AAWFPPX

(Modifications: Ala-1 = N-(Bz)Ala, Trp-3 = D-Trp, Pro-5 = D-Pro, X = Nle with C-terminal amide)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 141636-65-9
PubChem ID 5487475
Smiles [H]N([C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N1CCC[C@@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCC)C(N)=O)C(=O)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for GR 94800

Certificate of Analysis / Product Datasheet
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References for GR 94800

References are publications that support the biological activity of the product.

Matuszek et al (1998) An investigation of tachykinin NK2 receptor subtypes in the rat. Eur.J.Pharmacol. 352 103 PMID: 9718274

McElroy et al (1992) Highly potent and selective heptapeptide antagonists of the neurokinin NK-2 receptor. J.Med.Chem. 35 2582 PMID: 1321907

Zagorodnyuk et al (1995) Evidence that tachykinin NK1 and NK2 receptors mediate non-adrenergic non-cholinergic excitation and contraction in the circular muscle of guinea-pig duodenum. Br.J.Pharmacol. 115 237 PMID: 7545517

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Keywords: GR 94800, GR 94800 supplier, Potent, selective, NK2, antagonists, Tachykinin, Receptors, Neurokinin, GR94800, GlaxoSmithKline, GSK, Receptor, 1667, Tocris Bioscience

Citations for GR 94800

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Currently there are no citations for GR 94800.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

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Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.