GR 46611

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Cat.No. 0864 - GR 46611 | C23H27N3O2 | CAS No. 185259-85-2
Description: 5-HT1D agonist
Chemical Name: 3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide
Datasheet
Citations
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Literature

Biological Activity

5-HT1D receptor agonist. Blockade of GR 46611-induced hypothermia in the guinea pig provides a useful model with which to study the potency and duration of action of centrally acting 5-HT1D receptor ligands.

Licensing Information

Sold with the permission of GlaxoSmithKline

Compound Libraries

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Technical Data

M. Wt 377.49
Formula C23H27N3O2
Storage Store at RT
CAS Number 185259-85-2
PubChem ID 6160690
InChI Key LBVZWEWTNUDWNS-YRNVUSSQSA-N
Smiles O=C(/C=C/C2=CC=C(NC=C3CCN(C)C)C3=C2)NCC1=CC=C(OC)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 50 mM in DMSO and to 10 mM in ethanol

Preparing Stock Solutions

The following data is based on the product molecular weight 377.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.65 mL 13.25 mL 26.49 mL
5 mM 0.53 mL 2.65 mL 5.3 mL
10 mM 0.26 mL 1.32 mL 2.65 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

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Product Datasheets

Certificate of Analysis is currently unavailable
on-line. Please contact Customer Service
Safety Datasheet

References

References are publications that support the products' biological activity.

Clitherow et al (1994) Evolution of a novel series of [(N,N-Dimethylamino)propyl]- and piperazinylbenzanilides as the first selective 5-HT1D antagonists. J.Med.Chem. 37 2253 PMID: 8057272

Skingle et al (1994) Stimulation of central 5-HT1D receptors causes hypothermia in the guinea pig. J.Psychopharmacol. 8 14 PMID:


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