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Submit ReviewGR 46611
Description: 5-HT1D agonist
Chemical Name: 3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide
Biological Activity
5-HT1D receptor agonist. Blockade of GR 46611-induced hypothermia in the guinea pig provides a useful model with which to study the potency and duration of action of centrally acting 5-HT1D receptor ligands.
Licensing Information
Sold with the permission of GlaxoSmithKline
Technical Data
| M. Wt | 377.49 |
| Formula | C23H27N3O2 |
| Storage | Store at RT |
| CAS Number | 185259-85-2 |
| PubChem ID | 6160690 |
| InChI Key | LBVZWEWTNUDWNS-YRNVUSSQSA-N |
| Smiles | O=C(/C=C/C2=CC=C(NC=C3CCN(C)C)C3=C2)NCC1=CC=C(OC)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 50 | ||
| ethanol | 10 |
Preparing Stock Solutions
The following data is based on the product molecular weight 377.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.3 mL | 26.49 mL | 52.98 mL |
| 2.5 mM | 1.06 mL | 5.3 mL | 10.6 mL |
| 5 mM | 0.53 mL | 2.65 mL | 5.3 mL |
| 25 mM | 0.11 mL | 0.53 mL | 1.06 mL |
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Product Datasheets
Certificate of Analysis is currently unavailable on-line.
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References
References are publications that support the biological activity of the product.
Clitherow et al (1994) Evolution of a novel series of [(N,N-Dimethylamino)propyl]- and piperazinylbenzanilides as the first selective 5-HT1D antagonists. J.Med.Chem. 37 2253 PMID: 8057272
Skingle et al (1994) Stimulation of central 5-HT1D receptors causes hypothermia in the guinea pig. J.Psychopharmacol. 8 14
If you know of a relevant reference for GR 46611, please let us know.
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Keywords: GR 46611, GR 46611 supplier, 5-HT1D, agonists, Serotonin, Receptors, GR46611, GlaxoSmithKline, GSK, 0864, Tocris Bioscience
1 Citation for GR 46611
Citations are publications that use Tocris products. Selected citations for GR 46611 include:
Gu et al (2007) Effect of 5-hydroxytryptamine1 serotonin receptor agonists on noxiously stimulated micturition in cats with chronic spinal cord injury. J Urol 177 2381 PMID: 17509363
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