GR 46611
Biological Activity
5-HT1D receptor agonist. Blockade of GR 46611-induced hypothermia in the guinea pig provides a useful model with which to study the potency and duration of action of centrally acting 5-HT1D receptor ligands.
Licensing Information
Sold with the permission of GlaxoSmithKline
Compound Libraries
GR 46611 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 377.49 |
| Formula | C23H27N3O2 |
| Storage | Store at RT |
| CAS Number | 185259-85-2 |
| PubChem ID | 6160690 |
| InChI Key | LBVZWEWTNUDWNS-YRNVUSSQSA-N |
| Smiles | O=C(/C=C/C2=CC=C(NC=C3CCN(C)C)C3=C2)NCC1=CC=C(OC)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 50 mM in DMSO and to 10 mM in ethanol |
Preparing Stock Solutions
The following data is based on the product molecular weight 377.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.65 mL | 13.25 mL | 26.49 mL |
| 5 mM | 0.53 mL | 2.65 mL | 5.3 mL |
| 10 mM | 0.26 mL | 1.32 mL | 2.65 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.53 mL |
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Product Datasheets
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References
References are publications that support the products' biological activity.
Clitherow et al (1994) Evolution of a novel series of [(N,N-Dimethylamino)propyl]- and piperazinylbenzanilides as the first selective 5-HT1D antagonists. J.Med.Chem. 37 2253 PMID: 8057272
Skingle et al (1994) Stimulation of central 5-HT1D receptors causes hypothermia in the guinea pig. J.Psychopharmacol. 8 14 PMID:
If you know of a relevant reference for GR 46611, please let us know.
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Keywords: 5-HT1D agonists Serotonin Receptors GR46611 GlaxoSmithKline GSK 5-HT1D Receptors
Citations for GR 46611
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Literature in this Area
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Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
