GN 44028

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Cat.No. 5655 - GN 44028 | C18N15N3O2 | CAS No. 1421448-26-1
Description: Potent HIF-1α inhibitor
Chemical Name: N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine
Purity: ≥98% (HPLC)
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Citations
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Biological Activity

Potent HIF-1α inhibitor (IC50 = 14 nM). Inhibits hypoxia-induced HIF-1α transcriptional activity without suppressing HIF-1α mRNA expression, HIF-1α protein accumulation, or HIF-1α/HIF-1β heterodimerization. Cytotoxic to a range of cancer cell types in vitro.

Technical Data

M. Wt 305.33
Formula C18N15N3O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1421448-26-1
PubChem ID 71625259
InChI Key CGZKSZVSWAAUHE-UHFFFAOYSA-N
Smiles C12=CC=CC=C1C3=C(C(NC4=CC(OCCO5)=C5C=C4)=NN3)C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.53 100
ethanol 30.53 100

Preparing Stock Solutions

The following data is based on the product molecular weight 305.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.28 mL 16.38 mL 32.75 mL
5 mM 0.66 mL 3.28 mL 6.55 mL
10 mM 0.33 mL 1.64 mL 3.28 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Minegishi et al (2013) Discovery of indenopyrazoles as a new class of hypoxia inducible factor (HIF)-1 inhibitors. ACS Med.Chem.Lett. 4 297 PMID: 24900662


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View all Hypoxia Inducible Factor Inhibitors

Keywords: GN 44028, supplier, GN44028, HIF-1a, HIF-1alpha, HIF-1α, inhibitors, hypoxia-inducible, factors, inhibits, cytotoxic, HIF, Hypoxia, Inducible, Factors, HIF, Tocris Bioscience

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Cancer

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