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Biological Activity for GN 44028
GN 44028 is a potent HIF-1α inhibitor (IC50 = 14 nM). Inhibits hypoxia-induced HIF-1α transcriptional activity without suppressing HIF-1α mRNA expression, HIF-1α protein accumulation, or HIF-1α/HIF-1β heterodimerization. Cytotoxic to a range of cancer cell types in vitro.
Compound Libraries for GN 44028
Technical Data for GN 44028
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for GN 44028
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for GN 44028
The following data is based on the product molecular weight 305.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.28 mL||16.38 mL||32.75 mL|
|5 mM||0.66 mL||3.28 mL||6.55 mL|
|10 mM||0.33 mL||1.64 mL||3.28 mL|
|50 mM||0.07 mL||0.33 mL||0.66 mL|
References for GN 44028
References are publications that support the biological activity of the product.
Minegishi et al (2013) Discovery of indenopyrazoles as a new class of hypoxia inducible factor (HIF)-1 inhibitors. ACS Med.Chem.Lett. 4 297 PMID: 24900662
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Keywords: GN 44028, GN 44028 supplier, GN44028, HIF-1a, HIF-1alpha, HIF-1α, inhibitors, hypoxia-inducible, factors, inhibits, cytotoxic, Hypoxia, Inducible, Factors, 5655, Tocris Bioscience
Citations for GN 44028
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Literature in this Area
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