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Reversible, voltage-dependent CFTR chloride channel blocker (Ki = 4.3 μM). Inhibits forskolin-induced hyperpolarization in nasal potential differences and inhibits cholera toxin-induced intestinal fluid secretion in mice.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 493.15. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.03 mL||10.14 mL||20.28 mL|
|5 mM||0.41 mL||2.03 mL||4.06 mL|
|10 mM||0.2 mL||1.01 mL||2.03 mL|
|50 mM||0.04 mL||0.2 mL||0.41 mL|
References are publications that support the biological activity of the product.
Muanprasat et al (2004) Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy. J.Gen.Physiol. 124 125 PMID: 15277574
Norimatsu et al (2012) Locating a plausible binding site for an open-channel blocker, GlyH-101, in the pore of the cystic fibrosis transmembrane conductance regulator. Mol.Pharmacol. 82 1042 PMID: 22923500
If you know of a relevant reference for GlyH 101, please let us know.
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Keywords: GlyH 101, GlyH 101 supplier, GlyH101, Cl-, chloride, channels, blockers, CFTR, cystic, fibrosis, transmembrane, conductance, regulators, voltage, dependent, 5485, Tocris Bioscience
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