GlyH 101

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Cat.No. 5485 - GlyH 101 | C19H15Br2N3O3 | CAS No. 328541-79-3
Description: Reversible, voltage-dependent CFTR chloride channel blocker
Chemical Name: N-2-Naphthalenyl-2-[(3,5-dibromo-2,4-dihydroxyphenyl)methylene]glycine hydrazide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Reversible, voltage-dependent CFTR chloride channel blocker (Ki = 4.3 μM). Inhibits forskolin-induced hyperpolarization in nasal potential differences and inhibits cholera toxin-induced intestinal fluid secretion in mice.

Technical Data

M. Wt 493.15
Formula C19H15Br2N3O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 328541-79-3
PubChem ID 11260414
InChI Key FLGYCSPPJQJZCH-LCYFTJDESA-N
Smiles O=C(N/N=C/C3=C(O)C(Br)=C(O)C(Br)=C3)CNC2=CC1=CC=CC=C1C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 49.31 100

Preparing Stock Solutions

The following data is based on the product molecular weight 493.15. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.03 mL 10.14 mL 20.28 mL
5 mM 0.41 mL 2.03 mL 4.06 mL
10 mM 0.2 mL 1.01 mL 2.03 mL
50 mM 0.04 mL 0.2 mL 0.41 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Muanprasat et al (2004) Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy. J.Gen.Physiol. 124 125 PMID: 15277574

Norimatsu et al (2012) Locating a plausible binding site for an open-channel blocker, GlyH-101, in the pore of the cystic fibrosis transmembrane conductance regulator. Mol.Pharmacol. 82 1042 PMID: 22923500


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Keywords: GlyH 101, supplier, GlyH101, Cl-, chloride, channels, blockers, CFTR, cystic, fibrosis, transmembrane, conductance, regulators, voltage, dependent, CFTR, CFTR, Tocris Bioscience

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