GlyH 101

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Description: Reversible, voltage-dependent CFTR chloride channel blocker
Chemical Name: N-2-Naphthalenyl-2-[(3,5-dibromo-2,4-dihydroxyphenyl)methylene]glycine hydrazide
Purity: ≥97% (HPLC)

Biological Activity for GlyH 101

GlyH 101 is a reversible, voltage-dependent CFTR chloride channel blocker (Ki = 4.3 μM). Inhibits forskolin-induced hyperpolarization in nasal potential differences and inhibits cholera toxin-induced intestinal fluid secretion in mice.

Technical Data for GlyH 101

M. Wt 493.15
Formula C19H15Br2N3O3
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 328541-79-3
PubChem ID 11260414
Smiles O=C(N/N=C/C3=C(O)C(Br)=C(O)C(Br)=C3)CNC2=CC1=CC=CC=C1C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for GlyH 101

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 49.31 100

Preparing Stock Solutions for GlyH 101

The following data is based on the product molecular weight 493.15. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.03 mL 10.14 mL 20.28 mL
5 mM 0.41 mL 2.03 mL 4.06 mL
10 mM 0.2 mL 1.01 mL 2.03 mL
50 mM 0.04 mL 0.2 mL 0.41 mL

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Product Datasheets for GlyH 101

Certificate of Analysis / Product Datasheet
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References for GlyH 101

References are publications that support the biological activity of the product.

Muanprasat et al (2004) Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy. J.Gen.Physiol. 124 125 PMID: 15277574

Norimatsu et al (2012) Locating a plausible binding site for an open-channel blocker, GlyH-101, in the pore of the cystic fibrosis transmembrane conductance regulator. Mol.Pharmacol. 82 1042 PMID: 22923500

If you know of a relevant reference for GlyH 101, please let us know.

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Keywords: GlyH 101, GlyH 101 supplier, GlyH101, Cl-, chloride, channels, blockers, CFTR, cystic, fibrosis, transmembrane, conductance, regulators, voltage, dependent, 5485, Tocris Bioscience

Citations for GlyH 101

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