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Galloflavin

Cat. No. 4795 2 Citations 1 Review Submit a Review Datasheet / COA / SDS
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Description: Lactate dehydrogenase inhibitor; impairs aerobic glycolysis
Chemical Name: 3,8,9,10-Tetrahydroxypyrano[3,2-c][2]benzopyran-2,6-dione potassium salt
Purity: ≥95% (HPLC)
Datasheet
Citations (2)
Reviews (1)
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Galloflavin

Galloflavin is an inhibitor of human lactate dehydrogenase (LDH) (Ki values are 5.46 and 15.1 μM for LDH-A and LDH-B, respectively, in competition with pyruvate). Inhibits lactate production and decreases ATP synthesis in PLD/PRF/5 cells; thought to decrease cell viability via impairment of aerobic glycolysis.

Technical Data for Galloflavin

M. Wt 316.26
Formula C12H5O8K
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 1780260-20-9
PubChem ID 90488971
InChI Key XSPGPNGPTLAWMC-UHFFFAOYSA-M
Smiles [K+].OC1=C(O)C(O)=C2C3=C(OC(=O)C2=C1)C=C([O-])C(=O)O3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Galloflavin

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 1.58 5

Preparing Stock Solutions for Galloflavin

The following data is based on the product molecular weight 316.26. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 63.24 mL 316.2 mL 632.39 mL
0.25 mM 12.65 mL 63.24 mL 126.48 mL
0.5 mM 6.32 mL 31.62 mL 63.24 mL
2.5 mM 1.26 mL 6.32 mL 12.65 mL

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Product Datasheets for Galloflavin

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for Galloflavin

References are publications that support the biological activity of the product.

Manerba et al (2012) Galloflavin (CAS 568-80-9): a novel inhibitor of lactate dehydrogenase. ChemMedChem 7 311 PMID: 22052811

Fiume et al (2013) Galloflavin prevents the binding of lactate dehydrogenase A to single stranded DNA and inhibits RNA synthesis in cultured cells. Biochem.Biophys.Res.Commun. 430 466 PMID: 23237800

Farabegoli et al (2012) Galloflavin, a new lactate dehydrogenase inhibitor, induces the death of human breast cancer cells with different glycolytic attitude by affecting distinct signaling pathways. Eur.J.Pharm.Sci. 47 729 PMID: 22954722

If you know of a relevant reference for Galloflavin, please let us know.

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Keywords: Galloflavin, Galloflavin supplier, lactate, dehydrogenases, LDH-A, LDH-B, LDH, inhibitors, inhibits, aerobic, glycolysis, Lactate, Dehydrogenase, A, 4795, Tocris Bioscience

2 Citations for Galloflavin

Citations are publications that use Tocris products. Selected citations for Galloflavin include:

Dietmar et al (2020) Galloflavin Plus Metformin Treatment Impairs Pancreatic Cancer Cells. Anticancer Res 40 153-160 PMID: 31892563

Kottakis et al (2016) LKB1 loss links serine metabolism to DNA methylation and tumorigenesis. Nature 539 390 PMID: 27799657

Do you know of a great paper that uses Galloflavin from Tocris? Please let us know.

Reviews for Galloflavin

Average Rating: 5 (Based on 1 Review.)

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We got expected effect on cells.
By Anonymous on 04/03/2020
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Primary pancreatic ductal epithelial cells

20 μM galloflavin

review image

Literature in this Area

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