Galidesivir dihydrochloride

Pricing Availability   Qty
Cat.No. 7229 - Galidesivir dihydrochloride | C11H15N5O3.2HCl | CAS No. 1373208-51-5
Description: Viral RNA-dependent RNA polymerase (RdRP) inhibitor; broad spectrum antiviral
Alternative Names: BCX 4430
Chemical Name: (2S,3S,4R,5R)-2-(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)-3,4-pyrrolidinediol dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews

Biological Activity for Galidesivir dihydrochloride

Galidesivir is a viral RNA-dependent RNA polymerase (RdRP) inhibitor and broad spectrum antiviral nucleotide. In vitro, galidesivir displays antiviral activity against a range of RNA viruses, including bunyaviruses, arenaviruses, paramyxoviruses, coronaviruses, and flaviviruses (EC50 values range from 3 μM to >100 μM). Galidesivir protects against Ebola and Marburg viral infection in animal models.

Technical Data for Galidesivir dihydrochloride

M. Wt 338.19
Formula C11H15N5O3.2HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1373208-51-5
PubChem ID 90008271
InChI Key LOHGEHBUEDUIRK-PUSSMWDMSA-N
Smiles NC1=NC=NC2=C1NC=C2[C@@H]3N[C@@H]([C@H]([C@H]3O)O)CO.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Galidesivir dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 33.82 100
DMSO 16.91 50

Preparing Stock Solutions for Galidesivir dihydrochloride

The following data is based on the product molecular weight 338.19. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.96 mL 14.78 mL 29.57 mL
5 mM 0.59 mL 2.96 mL 5.91 mL
10 mM 0.3 mL 1.48 mL 2.96 mL
50 mM 0.06 mL 0.3 mL 0.59 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for Galidesivir dihydrochloride

References for Galidesivir dihydrochloride

References are publications that support the biological activity of the product.

Li & De Clercq (2020) Therapeutic options for the 2019 novel coronavirus (2019-nCoV). Nat.Rev.Drug Discov. 19 149 PMID: 32127666

Warren et al (2014) Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430. Nature. 508 402 PMID: 24590073


If you know of a relevant reference for Galidesivir dihydrochloride, please let us know.

View Related Products by Product Action

View all RNA Polymerase Inhibitors

Keywords: Galidesivir dihydrochloride, Galidesivir dihydrochloride supplier, Broad, spectrum, antiviral, rna-dependent, rna, polymerase, inhibitors, inhibits, RdRP, BCX, 4430, RNA, Polymerase, Non-selective, Antivirals, Coronavirus, 7229, Tocris Bioscience

Citations for Galidesivir dihydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for Galidesivir dihydrochloride. Do you know of a great paper that uses Galidesivir dihydrochloride from Tocris? Please let us know.

Reviews for Galidesivir dihydrochloride

There are currently no reviews for this product. Be the first to review Galidesivir dihydrochloride and earn rewards!

Have you used Galidesivir dihydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review