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Biological Activity for Galidesivir dihydrochloride
Galidesivir is a viral RNA-dependent RNA polymerase (RdRP) inhibitor and broad spectrum antiviral nucleotide. In vitro, galidesivir displays antiviral activity against a range of RNA viruses, including bunyaviruses, arenaviruses, paramyxoviruses, coronaviruses, and flaviviruses (EC50 values range from 3 μM to >100 μM). Galidesivir protects against Ebola and Marburg viral infection in animal models.
Technical Data for Galidesivir dihydrochloride
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Galidesivir dihydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Galidesivir dihydrochloride
The following data is based on the product molecular weight 338.19. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.96 mL||14.78 mL||29.57 mL|
|5 mM||0.59 mL||2.96 mL||5.91 mL|
|10 mM||0.3 mL||1.48 mL||2.96 mL|
|50 mM||0.06 mL||0.3 mL||0.59 mL|
Product Datasheets for Galidesivir dihydrochloride
References for Galidesivir dihydrochloride
References are publications that support the biological activity of the product.
Li & De Clercq (2020) Therapeutic options for the 2019 novel coronavirus (2019-nCoV). Nat.Rev.Drug Discov. 19 149 PMID: 32127666
Warren et al (2014) Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430. Nature. 508 402 PMID: 24590073
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Citations for Galidesivir dihydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for Galidesivir dihydrochloride. Do you know of a great paper that uses Galidesivir dihydrochloride from Tocris? Please let us know.
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