Galidesivir dihydrochloride

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Description: Viral RNA-dependent RNA polymerase (RdRP) inhibitor; broad spectrum antiviral
Alternative Names: BCX 4430
Chemical Name: (2S,3S,4R,5R)-2-(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)-3,4-pyrrolidinediol dihydrochloride
Purity: ≥98% (HPLC)

Biological Activity for Galidesivir dihydrochloride

Galidesivir is a viral RNA-dependent RNA polymerase (RdRP) inhibitor and broad spectrum antiviral nucleotide. In vitro, galidesivir displays antiviral activity against a range of RNA viruses, including bunyaviruses, arenaviruses, paramyxoviruses, coronaviruses, and flaviviruses (EC50 values range from 3 μM to >100 μM). Galidesivir protects against Ebola and Marburg viral infection in animal models.

Technical Data for Galidesivir dihydrochloride

M. Wt 338.19
Formula C11H15N5O3.2HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1373208-51-5
PubChem ID 90008271
Smiles NC1=NC=NC2=C1NC=C2[C@@H]3N[C@@H]([C@H]([C@H]3O)O)CO.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Galidesivir dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 33.82 100
DMSO 16.91 50

Preparing Stock Solutions for Galidesivir dihydrochloride

The following data is based on the product molecular weight 338.19. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.96 mL 14.78 mL 29.57 mL
5 mM 0.59 mL 2.96 mL 5.91 mL
10 mM 0.3 mL 1.48 mL 2.96 mL
50 mM 0.06 mL 0.3 mL 0.59 mL

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Product Datasheets for Galidesivir dihydrochloride

References for Galidesivir dihydrochloride

References are publications that support the biological activity of the product.

Li & De Clercq (2020) Therapeutic options for the 2019 novel coronavirus (2019-nCoV). Nat.Rev.Drug Discov. 19 149 PMID: 32127666

Warren et al (2014) Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430. Nature. 508 402 PMID: 24590073

If you know of a relevant reference for Galidesivir dihydrochloride, please let us know.

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Citations for Galidesivir dihydrochloride

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