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Calcium-sensing receptor (CaSR) agonist; induces NLRP3 inflammasome activation in bone marrow-derived macrophages. Blocks stretch-activated calcium channels; inhibits increase in intracellular calcium ion concentration in hypotonic-stimulated pulmonary artery smooth muscle cells. Has been demonstrated to block TRPML channel currents and other TRP channels.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 263.61. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.79 mL||18.97 mL||37.93 mL|
|5 mM||0.76 mL||3.79 mL||7.59 mL|
|10 mM||0.38 mL||1.9 mL||3.79 mL|
|50 mM||0.08 mL||0.38 mL||0.76 mL|
References are publications that support the biological activity of the product.
Nishitani et al (2011) Calcium signaling in live cells on elastic gels under mechanical vibration at subcellular levels. PLoS One. 6 e26181 PMID: 22053183
Lee et al (2012) The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature 492 123 PMID: 23143333
Del Favero et al (2012) The stretch-activated channel blocker Gd3+ reduces palytoxin toxicity in primary cultures of skeletal muscle cells. Chem.Res.Toxicol. 25 1912 PMID: 22900474
Nagata et al (2008) The varitint-waddler (Va) deafness mutation in TRPML3 generates constitutive, inward rectifying currents and causes cell degeneration. Proc.Natl.Acad.Sci.U.S.A. 105 353 PMID: 18162548
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Keywords: Gadolinium chloride, Gadolinium chloride supplier, CaSR, calcium, sensing, receptors, agonists, stretch, activated, channels, blockers, TRP, TRPML, Other, Calcium, Channels, Calcium-Sensing, Receptor, 4741, Tocris Bioscience
3 Citations for Gadolinium chloride
Citations are publications that use Tocris products. Selected citations for Gadolinium chloride include:
Dela Paz (2018) Yoda1-induced phosphorylation of Akt and ERK1/2 does not require Piezo1 activation. Biochem Biophys Res Commun 497 220 PMID: 29428723
Szteyn et al (2015) Divergence in endothelin-1- and bradykinin-activated store-operated calcium entry in afferent sensory neurons. J Immunol 7 PMID: 25873305
Yin et al (2017) Quantum dots modulate intracellular Ca2+level in lung epithelial cells. Int J Nanomedicine 12 2781 PMID: 28435258
Do you know of a great paper that uses Gadolinium chloride from Tocris? Please let us know.
Reviews for Gadolinium chloride
Average Rating: 5 (Based on 1 Review.)
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we used it to inhibit store-operated calcium channels, more specifically Calcium release activated channels (CRAC). Worked as expected although some changes to the media was needed.