Gadolinium chloride

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Cat.No. 4741 - Gadolinium chloride | GdCl3 | CAS No. 10138-52-0
Description: Stretch-activated calcium channel blocker; calcium-sensing receptor agonist
Datasheet
Citations (1)

Biological Activity

Calcium-sensing receptor (CaSR) agonist; induces NLRP3 inflammasome activation in bone marrow-derived macrophages. Blocks stretch-activated calcium channels; inhibits increase in intracellular calcium ion concentration in hypotonic-stimulated pulmonary artery smooth muscle cells. Has been demonstrated to block TRPML channel currents and other TRP channels.

Technical Data

M. Wt 263.61
Formula GdCl3
Storage Desiccate at RT
CAS Number 10138-52-0
PubChem ID 61486
InChI Key MEANOSLIBWSCIT-UHFFFAOYSA-K
Smiles Cl[Gd](Cl)Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 26.36 100

Preparing Stock Solutions

The following data is based on the product molecular weight 263.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.79 mL 18.97 mL 37.93 mL
5 mM 0.76 mL 3.79 mL 7.59 mL
10 mM 0.38 mL 1.9 mL 3.79 mL
50 mM 0.08 mL 0.38 mL 0.76 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Nishitani et al (2011) Calcium signaling in live cells on elastic gels under mechanical vibration at subcellular levels. PLoS One. 6 e26181 PMID: 22053183

Lee et al (2012) The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature 492 123 PMID: 23143333

Del Favero et al (2012) The stretch-activated channel blocker Gd3+ reduces palytoxin toxicity in primary cultures of skeletal muscle cells. Chem.Res.Toxicol. 25 1912 PMID: 22900474

Nagata et al (2008) The varitint-waddler (Va) deafness mutation in TRPML3 generates constitutive, inward rectifying currents and causes cell degeneration. Proc.Natl.Acad.Sci.U.S.A. 105 353 PMID: 18162548


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Keywords: Gadolinium chloride, supplier, CaSR, calcium, sensing, receptors, agonists, stretch, activated, calcium, channels, blockers, TRP, TRPML, Other, Calcium, Channels, Calcium-Sensing, Receptor, TRPML, Other, Calcium, Channels, Tocris Bioscience

1 Citation for Gadolinium chloride

Citations are publications that use Tocris products. Selected citations for Gadolinium chloride include:

Szteyn et al (2015) Divergence in endothelin-1- and bradykinin-activated store-operated calcium entry in afferent sensory neurons. J Immunol 7 PMID: 25873305


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