Gadolinium chloride

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Description: Stretch-activated calcium channel blocker; calcium-sensing receptor agonist
Citations (6)
Reviews (1)

Biological Activity for Gadolinium chloride

Gadolinium chloride is a calcium-sensing receptor (CaSR) agonist; induces NLRP3 inflammasome activation in bone marrow-derived macrophages. Blocks stretch-activated calcium channels; inhibits increase in intracellular calcium ion concentration in hypotonic-stimulated pulmonary artery smooth muscle cells. Has been demonstrated to block TRPML channel currents and other TRP channels.

Technical Data for Gadolinium chloride

M. Wt 263.61
Formula GdCl3
Storage Desiccate at RT
CAS Number 10138-52-0
PubChem ID 61486
Smiles Cl[Gd](Cl)Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Gadolinium chloride

Solvent Max Conc. mg/mL Max Conc. mM
water 26.36 100

Preparing Stock Solutions for Gadolinium chloride

The following data is based on the product molecular weight 263.61. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.79 mL 18.97 mL 37.93 mL
5 mM 0.76 mL 3.79 mL 7.59 mL
10 mM 0.38 mL 1.9 mL 3.79 mL
50 mM 0.08 mL 0.38 mL 0.76 mL

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Product Datasheets for Gadolinium chloride

Certificate of Analysis / Product Datasheet
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References for Gadolinium chloride

References are publications that support the biological activity of the product.

Nishitani et al (2011) Calcium signaling in live cells on elastic gels under mechanical vibration at subcellular levels. PLoS One. 6 e26181 PMID: 22053183

Lee et al (2012) The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature 492 123 PMID: 23143333

Del Favero et al (2012) The stretch-activated channel blocker Gd3+ reduces palytoxin toxicity in primary cultures of skeletal muscle cells. Chem.Res.Toxicol. 25 1912 PMID: 22900474

Nagata et al (2008) The varitint-waddler (Va) deafness mutation in TRPML3 generates constitutive, inward rectifying currents and causes cell degeneration. Proc.Natl.Acad.Sci.U.S.A. 105 353 PMID: 18162548

If you know of a relevant reference for Gadolinium chloride, please let us know.

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Keywords: Gadolinium chloride, Gadolinium chloride supplier, CaSR, calcium, sensing, receptors, agonists, stretch, activated, channels, blockers, TRP, TRPML, Other, Calcium, Channels, Calcium-Sensing, Receptor, 4741, Tocris Bioscience

6 Citations for Gadolinium chloride

Citations are publications that use Tocris products. Selected citations for Gadolinium chloride include:

Ina et al (2020) Binding Dynamics of α-Actinin-4 in Dependence of Actin Cortex Tension. Biophys J 119 1091-1107 PMID: 32853564

Yin et al (2017) Quantum dots modulate intracellular Ca2+level in lung epithelial cells. Int J Nanomedicine 12 2781 PMID: 28435258

Szteyn et al (2015) Divergence in endothelin-1- and bradykinin-activated store-operated calcium entry in afferent sensory neurons. J Immunol 7 PMID: 25873305

Mark S et al (2021) Augmented KCa2.3 Channel Feedback Regulation of Oxytocin Stimulated Uterine Strips from Nonpregnant Mice. Int J Mol Sci 22 PMID: 34948381

Dela Paz (2018) Yoda1-induced phosphorylation of Akt and ERK1/2 does not require Piezo1 activation. Biochem Biophys Res Commun 497 220 PMID: 29428723

François et al (2022) Role of Ion Channels in the Maintenance of Sperm Motility and Swimming Behavior in a Marine Teleost. Int J Mol Sci 23 PMID: 36292967

Do you know of a great paper that uses Gadolinium chloride from Tocris? Please let us know.

Reviews for Gadolinium chloride

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CRAC blocker.
By Anonymous on 11/19/2018
Assay Type: Ex Vivo
Species: Mouse

we used it to inhibit store-operated calcium channels, more specifically Calcium release activated channels (CRAC). Worked as expected although some changes to the media was needed.