G5

Pricing Availability   Qty
Cat.No. 6776 - G5 | C19H14N2O7S | CAS No. 108477-18-5
Description: Ubiquitin isopeptidase inhibitor; induces apoptosis
Chemical Name: Tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-4H-thiopyran-4-one-1,1-dioxide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Ubiquitin isopeptidase inhibitor; activates caspases and apoptosis in an apoptosome-independent pathway.

Technical Data

M. Wt 414.39
Formula C19H14N2O7S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 108477-18-5
PubChem ID 5918438
InChI Key SSAMIOWVUGBIJK-KAVGSWPWSA-N
Smiles O=C1/C(CS(=O)(C/C1=C\C2=CC=C([N+]([O-])=O)C=C2)=O)=C/C3=CC=C([N+]([O-])=O)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.72 50

Preparing Stock Solutions

The following data is based on the product molecular weight 414.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.83 mL 24.13 mL 48.26 mL
2.5 mM 0.97 mL 4.83 mL 9.65 mL
5 mM 0.48 mL 2.41 mL 4.83 mL
25 mM 0.1 mL 0.48 mL 0.97 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Hafner-Bratkovic et al (2018) NLRP3 lacking the leucine-rich repeat domain can be fully activated via the canonical inflammasome pathway. Nat.Commun. 9 5182 PMID: 30518920

Foti et al (2009) Characterization of caspase-dependent and caspase-independent deaths in glioblastoma cells treated with inhibitors of the ubiquitin-proteasome system. Mol.Cancer Ther. 8 3140 PMID: 19887551

Aleo et al (2006) Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis. Cancer Res. 66 9235 PMID: 16982768


If you know of a relevant reference for G5, please let us know.

View Related Products by Product Action

View all Deubiquitinating Enzyme Inhibitors

Keywords: G5, G5 supplier, Ubiquitin, isopeptidases, inhibitors, inhibits, caspases, activators, apoptosis, inducers, Deubiquitinating, Enzymes, Apoptosis, Inducers, 6776, Tocris Bioscience

Citations for G5

Citations are publications that use Tocris products.

Currently there are no citations for G5. Do you know of a great paper that uses G5 from Tocris? Please let us know.

Reviews for G5

There are currently no reviews for this product. Be the first to review G5 and earn rewards!

Have you used G5?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


New Product Guide

New Product Guide (Fall/Winter 2018/2019)

Our new product guide highlights over 190 new products added to the Tocris Bioscience range during the second half of 2018.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Chemogenetics
  • Epigenetics
  • Fluorescent Imaging
  • PROTACs
  • Signal Transduction
  • Stem Cells