γ1-MSH

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Cat.No. 3424 - gamma1-MSH | Tyr-Val-Met-Gly-His-Phe-Arg-Trp-Asp-Arg-Phe-NH2 | CAS No. 72629-65-3
Description: Selective MC3 receptor agonist
Datasheet
Citations (1)
Reviews
Literature (3)

Biological Activity

Endogenous melanocortin MC3 receptor agonist (pKi = 7.46) that displays ~ 40-fold selectivity over MC4. Increases the release of extracellular dopamine, which induces grooming and vertical activity (rearing) in rats. Exhibits hypertensive, tachycardic and short-term analgesic activity in vivo.

Technical Data

M. Wt 1512.76
Formula C72H97N21O14S
Sequence YVMGHFRWDRF

(Modifications: Phe-11 = C-terminal amide)

Storage Store at -20°C
CAS Number 72629-65-3
PubChem ID 57339641
InChI Key SLEIICTWQFRIFM-SLNSXFHGSA-N
Smiles [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 2 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Versteeg et al (1998) Melanocortins and cardiovascular regulation. Eur.J.Pharmacol. 360 1 PMID: 9845266

Lindblom et al (1998) Autoradiographic discrimination of melanocortin receptors indicates that the MC3 subtype dominates in the medial rat brain. Brain Res. 810 161 PMID: 9813305

Jansone et al (2004) Opposite effects of γ1- and γ2-melanocyte stimulating hormone on regulation of the DArgic mesolimbic system in rats. Neurosci.Lett. 361 68 PMID: 15135895


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Keywords: gamma1-MSH, gamma1-MSH supplier, Selective, MC3R, receptor, agonists, Receptors, Melanocortin, γ1-MSH, gamma1-MSH, 3424, Tocris Bioscience

1 Citation for γ1-MSH

Citations are publications that use Tocris products. Selected citations for γ1-MSH include:

Nøhr et al (2017) The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW. Neurochem Int 102 105 PMID: 27916541


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Literature in this Area

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