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Submit ReviewG-Protein antagonist peptide
Description: Inhibits G protein activation by GPCRs
Alternative Names: GPAnt-2
Biological Activity
Substance P-related peptide that inhibits binding of G proteins to their receptors. Competitively and reversibly inhibits M2 muscarinic receptor activation of Gi or Go and inhibits Gs activation by β-adrenoceptors.
Technical Data
| M. Wt | 1093.27 |
| Formula | C57H64N12O9S |
| Sequence |
XQWFWWM (Modifications: X = Glp, Trp-3 = Trp-5 = Trp-6 = D-Trp, Met-7 = C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 143675-79-0 |
| PubChem ID | 71308571 |
| InChI Key | WSYRBHQWMXTCHQ-SFIKJRKMSA-N |
| Smiles | [H]N1[C@@H](CCC1=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCSC)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solubility | Soluble to 2 mg/ml in DMSO |
Product Datasheets
References
References are publications that support the biological activity of the product.
Mukai et al (1992) G protein antagonists. A novel hydrophobic peptide competes with receptor for G protein binding. J.Biol.Chem. 267 16237 PMID: 1379592
If you know of a relevant reference for G-Protein antagonist peptide, please let us know.
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2 Citations for G-Protein antagonist peptide
Citations are publications that use Tocris products. Selected citations for G-Protein antagonist peptide include:
Akoume et al (2019) A Differential Hypofunctionality of Gαi Proteins Occurs in Adolescent Idiopathic Scoliosis and Correlates with the Risk of Disease Progression. Sci Rep 9 10074 PMID: 31296888
Nogueras-Ortiz (2017) Retromer stops beta-arrestin 1 mediated signaling from internalized cannabinoid 2 receptors. Mol Biol Cell 28 3554 PMID: 28954865
Do you know of a great paper that uses G-Protein antagonist peptide from Tocris? Please let us know.
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