G-Protein antagonist peptide

Pricing Availability Delivery Time Qty
Cat.No. 1931 - G-Protein Antagonist peptide | Glp-Gln-D-Trp-Phe-D-Trp-D-Trp-Met-NH2 | CAS No. 143675-79-0
Description: Inhibits G protein activation by GPCRs
Alternative Names: GPAnt-2
Citations (1)

Biological Activity

Substance P-related peptide that inhibits binding of G proteins to their receptors. Competitively and reversibly inhibits M2 muscarinic receptor activation of Gi or Go and inhibits Gs activation by β-adrenoceptors.

Technical Data

M. Wt 1093.27
Formula C57H64N12O9S
Sequence XQWFWWM

(Modifications: X = Glp, Trp-3 = Trp-5 = Trp-6 = D-Trp, Met-7 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 143675-79-0
PubChem ID 71308571
Smiles [H]N1[C@@H](CCC1=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCSC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 2 mg/ml in DMSO

Preparing Stock Solutions

The following data is based on the product molecular weight 1093.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.91 mL 4.57 mL 9.15 mL
5 mM 0.18 mL 0.91 mL 1.83 mL
10 mM 0.09 mL 0.46 mL 0.91 mL
50 mM 0.02 mL 0.09 mL 0.18 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet


References are publications that support the products' biological activity.

Mukai et al (1992) G protein antagonists. A novel hydrophobic peptide competes with receptor for G protein binding. J.Biol.Chem. 267 16237 PMID: 1379592

If you know of a relevant reference for G-Protein antagonist peptide, please let us know.

View Related Products by Target

View Related Products by Product Action

View all G Protein (Heterotrimeric) Inhibitors

Keywords: G-Protein Antagonist peptide, supplier, inhibitors, inhibits, G, protein, activation, by, GPCRs, Gi, Go, Gs, G-Protein, Heterotrimeric, antagonists, GPAnt2, substance, P, GPAnt-2, G, Protein, (Heterotrimeric), G, Protein, (Heterotrimeric), Tocris Bioscience

1 Citation for G-Protein antagonist peptide

Citations are publications that use Tocris products. Selected citations for G-Protein antagonist peptide include:

Nogueras-Ortiz (2017) Retromer stops beta-arrestin 1 mediated signaling from internalized cannabinoid 2 receptors. Mol Biol Cell 28 3554 PMID: 28954865

Do you know of a great paper that uses G-Protein antagonist peptide from Tocris? If so please let us know.

Reviews for G-Protein antagonist peptide

There are currently no reviews for this product. Be the first to review G-Protein antagonist peptide and earn rewards!

Have you used G-Protein antagonist peptide?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling