G-Protein antagonist peptide
Substance P-related peptide that inhibits binding of G proteins to their receptors. Competitively and reversibly inhibits M2 muscarinic receptor activation of Gi or Go and inhibits Gs activation by β-adrenoceptors.
(Modifications: X = Glp, Trp-3 = Trp-5 = Trp-6 = D-Trp, Met-7 = C-terminal amide)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 2 mg/ml in DMSO|
References are publications that support the biological activity of the product.
Mukai et al (1992) G protein antagonists. A novel hydrophobic peptide competes with receptor for G protein binding. J.Biol.Chem. 267 16237 PMID: 1379592
If you know of a relevant reference for G-Protein antagonist peptide, please let us know.
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1 Citation for G-Protein antagonist peptide
Citations are publications that use Tocris products. Selected citations for G-Protein antagonist peptide include:
Nogueras-Ortiz (2017) Retromer stops beta-arrestin 1 mediated signaling from internalized cannabinoid 2 receptors. Mol Biol Cell 28 3554 PMID: 28954865
Do you know of a great paper that uses G-Protein antagonist peptide from Tocris? Please let us know.
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