G-Protein antagonist peptide
Biological Activity
Substance P-related peptide that inhibits binding of G proteins to their receptors. Competitively and reversibly inhibits M2 muscarinic receptor activation of Gi or Go and inhibits Gs activation by β-adrenoceptors.
Technical Data
| M. Wt | 1093.27 |
| Formula | C57H64N12O9S |
| Sequence |
XQWFWWM (Modifications: X = Glp, Trp-3 = Trp-5 = Trp-6 = D-Trp, Met-7 = C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 143675-79-0 |
| PubChem ID | 71308571 |
| InChI Key | WSYRBHQWMXTCHQ-SFIKJRKMSA-N |
| Smiles | [H]N1[C@@H](CCC1=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCSC)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 2 mg/ml in DMSO |
Preparing Stock Solutions
The following data is based on the product molecular weight 1093.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.91 mL | 4.57 mL | 9.15 mL |
| 5 mM | 0.18 mL | 0.91 mL | 1.83 mL |
| 10 mM | 0.09 mL | 0.46 mL | 0.91 mL |
| 50 mM | 0.02 mL | 0.09 mL | 0.18 mL |
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References
References are publications that support the products' biological activity.
Mukai et al (1992) G protein antagonists. A novel hydrophobic peptide competes with receptor for G protein binding. J.Biol.Chem. 267 16237 PMID: 1379592
If you know of a relevant reference for G-Protein antagonist peptide, please let us know.
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Keywords: G-Protein Antagonist peptide, supplier, inhibitors, inhibits, G, protein, activation, by, GPCRs, Gi, Go, Gs, G-Protein, Heterotrimeric, antagonists, GPAnt2, substance, P, GPAnt-2, G, Protein, (Heterotrimeric), Tocris Bioscience
Citations for G-Protein antagonist peptide
Citations are publications that use Tocris products.
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