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G-Protein antagonist peptide
Discontinued ProductG-Protein antagonist peptide (Cat. No. 1931) has been withdrawn from sale for commercial reasons.
Biological Activity for G-Protein antagonist peptide
G-Protein antagonist peptide is a substance P-related peptide that inhibits binding of G proteins to their receptors. Competitively and reversibly inhibits M2 muscarinic receptor activation of Gi or Go and inhibits Gs activation by β-adrenoceptors.
Technical Data for G-Protein antagonist peptide
(Modifications: X = Glp, Trp-3 = Trp-5 = Trp-6 = D-Trp, Met-7 = C-terminal amide)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for G-Protein antagonist peptide
References for G-Protein antagonist peptide
References are publications that support the biological activity of the product.
Mukai et al (1992) G protein antagonists. A novel hydrophobic peptide competes with receptor for G protein binding. J.Biol.Chem. 267 16237 PMID: 1379592
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Keywords: G-Protein Antagonist peptide, G-Protein Antagonist peptide supplier, inhibitors, inhibits, G, protein, activation, by, GPCRs, Gi, Go, Gs, G-Protein, Heterotrimeric, antagonists, GPAnt2, substance, P, GPAnt-2, G-protein, GTPases, 1931, Tocris Bioscience
2 Citations for G-Protein antagonist peptide
Citations are publications that use Tocris products. Selected citations for G-Protein antagonist peptide include:
Akoume et al (2019) A Differential Hypofunctionality of Gαi Proteins Occurs in Adolescent Idiopathic Scoliosis and Correlates with the Risk of Disease Progression. Sci Rep 9 10074 PMID: 31296888
Nogueras-Ortiz (2017) Retromer stops beta-arrestin 1 mediated signaling from internalized cannabinoid 2 receptors. Mol Biol Cell 28 3554 PMID: 28954865
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Literature in this Area
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