G-Protein antagonist peptide

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Cat.No. 1931 - G-Protein Antagonist peptide | Glp-Gln-D-Trp-Phe-D-Trp-D-Trp-Met-NH2 | CAS No. 143675-79-0
Description: Inhibits G protein activation by GPCRs
Alternative Names: GPAnt-2
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Substance P-related peptide that inhibits binding of G proteins to their receptors. Competitively and reversibly inhibits M2 muscarinic receptor activation of Gi or Go and inhibits Gs activation by β-adrenoceptors.

Technical Data

M. Wt 1093.27
Formula C57H64N12O9S
Sequence XQWFWWM

(Modifications: X = Glp, Trp-3 = Trp-5 = Trp-6 = D-Trp, Met-7 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 143675-79-0
PubChem ID 71308571
InChI Key WSYRBHQWMXTCHQ-SFIKJRKMSA-N
Smiles [H]N1[C@@H](CCC1=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCSC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 2 mg/ml in DMSO

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Mukai et al (1992) G protein antagonists. A novel hydrophobic peptide competes with receptor for G protein binding. J.Biol.Chem. 267 16237 PMID: 1379592


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1 Citation for G-Protein antagonist peptide

Citations are publications that use Tocris products. Selected citations for G-Protein antagonist peptide include:

Nogueras-Ortiz (2017) Retromer stops beta-arrestin 1 mediated signaling from internalized cannabinoid 2 receptors. Mol Biol Cell 28 3554 PMID: 28954865


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