Fumonisin B1

Discontinued Product

Fumonisin B1 (Cat. No. 3103) has been withdrawn from sale for commercial reasons.
Description: Inhibitor of sphingosine N-acyltransferase
Chemical Name: 1,1'-[(1S,2R)-1-[(2S,4R,9R,11S,12S)-12-Amino-4,9,11-trihydroxy-2-methyltridecyl]-2-[(1R)-1-methylpentyl]-1,2-ethanediyl-1,2,3-(2R,2'R)-propanetricarboxylic acid ester.
Datasheet
Citations
Reviews

Biological Activity for Fumonisin B1

Fumonisin B1 is a mycotoxin produced by Fusarium moniliforme. Potently inhibits sphingosine N-acyltransferase (ceramide synthase), causing an accumulation of sphingoid bases (IC50 ~ 75 nM). Also inhibits protein phosphatases; IC50 values are 80, 300, 400, 500 and 3000 μM for PP5, PP2Cα, PP2A, PP1γ2 and PP2B respectively.

Technical Data for Fumonisin B1

M. Wt 721.83
Formula C34H59NO15
Storage Store at +4°C
CAS Number 116355-83-0
PubChem ID 2733487
InChI Key UVBUBMSSQKOIBE-DSLOAKGESA-N
Smiles C[C@H](N)[C@@H](O)C[C@H](O)CCCC[C@@H](O)C[C@H](C)C[C@H](OC(C[C@H]([C@@](O)=O)CC(O)=O)=O)[C@H](OC(C[C@H]([C@@](O)=O)CC(O)=O)=O)[C@H](C)CCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Fumonisin B1

Certificate of Analysis / Product Datasheet
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References for Fumonisin B1

References are publications that support the biological activity of the product.

Merrill et al (1993) Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ. J.Biol.Chem. 268 27299 PMID: 8262970

Blazquez et al (2008) Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression. Cancer Res. 68 1945 PMID: 18339876

Fukuda et al (1996) Inhibition of protein serine/threonine phosphatases by Fumonisin B1, a mycotoxin. Biochem.Biophys.Res.Comms. 220 160

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Keywords: Fumonisin B1, Fumonisin B1 supplier, inhibitors, inhibits, Ser/Thr, protein, phosphatases, Transferases, sphingosine, N-acyltransferase, ceramide, synthase, FumonisinB1, Protein, Phosphatases, Other, 3103, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Fumonisin B1, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov

Citations for Fumonisin B1

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