Mycotoxin produced by Fusarium moniliforme. Potently inhibits sphingosine N-acyltransferase (ceramide synthase), causing an accumulation of sphingoid bases (IC50 ~ 75 nM). Also inhibits protein phosphatases; IC50 values are 80, 300, 400, 500 and 3000 μM for PP5, PP2Cα, PP2A, PP1γ2 and PP2B respectively.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 721.83. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.39 mL||6.93 mL||13.85 mL|
|5 mM||0.28 mL||1.39 mL||2.77 mL|
|10 mM||0.14 mL||0.69 mL||1.39 mL|
|50 mM||0.03 mL||0.14 mL||0.28 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Merrill et al (1993) Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ. J.Biol.Chem. 268 27299 PMID: 8262970
Blazquez et al (2008) Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression. Cancer Res. 68 1945 PMID: 18339876
If you know of a relevant reference for Fumonisin B1, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Fumonisin B1, supplier, inhibitors, inhibits, Ser/Thr, protein, phosphatases, Transferases, sphingosine, N-acyltransferase, ceramide, synthase, FumonisinB1, Other, Transferases, Tocris Bioscience
Citations for Fumonisin B1
Citations are publications that use Tocris products.
Currently there are no citations for Fumonisin B1. Do you know of a great paper that uses Fumonisin B1 from Tocris? If so please let us know.
Literature in this Area
New Product Guide (Spring/Summer 2017)New
Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.
- 7-TM Receptors
- Enzyme-Linked Receptors
- Ion Channels
- Nuclear Receptors
- Cell Metabolism
- Fluorescent Imaging
- Signal Transduction
- Stem Cells