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Mycotoxin produced by Fusarium moniliforme. Potently inhibits sphingosine N-acyltransferase (ceramide synthase), causing an accumulation of sphingoid bases (IC50 ~ 75 nM). Also inhibits protein phosphatases; IC50 values are 80, 300, 400, 500 and 3000 μM for PP5, PP2Cα, PP2A, PP1γ2 and PP2B respectively.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 721.83. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||13.85 mL||69.27 mL||138.54 mL|
|0.5 mM||2.77 mL||13.85 mL||27.71 mL|
|1 mM||1.39 mL||6.93 mL||13.85 mL|
|5 mM||0.28 mL||1.39 mL||2.77 mL|
References are publications that support the biological activity of the product.
Merrill et al (1993) Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ. J.Biol.Chem. 268 27299 PMID: 8262970
Blazquez et al (2008) Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression. Cancer Res. 68 1945 PMID: 18339876
Fukuda et al (1996) Inhibition of protein serine/threonine phosphatases by Fumonisin B1, a mycotoxin. Biochem.Biophys.Res.Comms. 220 160
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Keywords: Fumonisin B1, Fumonisin B1 supplier, inhibitors, inhibits, Ser/Thr, protein, phosphatases, Transferases, sphingosine, N-acyltransferase, ceramide, synthase, FumonisinB1, Protein, Phosphatases, Other, 3103, Tocris Bioscience
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