Fumonisin B1

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Cat.No. 3103 - Fumonisin B1 | C34H59NO15 | CAS No. 116355-83-0
Description: Inhibitor of sphingosine N-acyltransferase
Chemical Name: 1,1'-[(1S,2R)-1-[(2S,4R,9R,11S,12S)-12-Amino-4,9,11-trihydroxy-2-methyltridecyl]-2-[(1R)-1-methylpentyl]-1,2-ethanediyl-1,2,3-(2R,2'R)-propanetricarboxylic acid ester.
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

Mycotoxin produced by Fusarium moniliforme. Potently inhibits sphingosine N-acyltransferase (ceramide synthase), causing an accumulation of sphingoid bases (IC50 ~ 75 nM). Also inhibits protein phosphatases; IC50 values are 80, 300, 400, 500 and 3000 μM for PP5, PP2Cα, PP2A, PP1γ2 and PP2B respectively.

Technical Data

M. Wt 721.83
Formula C34H59NO15
Storage Store at +4°C
CAS Number 116355-83-0
PubChem ID 2733487
InChI Key UVBUBMSSQKOIBE-DSLOAKGESA-N
Smiles C[C@H](N)[C@@H](O)C[C@H](O)CCCC[C@@H](O)C[C@H](C)C[C@H](OC(C[C@H]([C@@](O)=O)CC(O)=O)=O)[C@H](OC(C[C@H]([C@@](O)=O)CC(O)=O)=O)[C@H](C)CCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.22 10

Preparing Stock Solutions

The following data is based on the product molecular weight 721.83. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 13.85 mL 69.27 mL 138.54 mL
0.5 mM 2.77 mL 13.85 mL 27.71 mL
1 mM 1.39 mL 6.93 mL 13.85 mL
5 mM 0.28 mL 1.39 mL 2.77 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Merrill et al (1993) Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ. J.Biol.Chem. 268 27299 PMID: 8262970

Blazquez et al (2008) Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression. Cancer Res. 68 1945 PMID: 18339876

Fukuda et al (1996) Inhibition of protein serine/threonine phosphatases by Fumonisin B1, a mycotoxin. Biochem.Biophys.Res.Comms. 220 160


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Keywords: Fumonisin B1, Fumonisin B1 supplier, inhibitors, inhibits, Ser/Thr, protein, phosphatases, Transferases, sphingosine, N-acyltransferase, ceramide, synthase, FumonisinB1, Protein, Phosphatases, Other, 3103, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Fumonisin B1, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov

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