FSEN 1

Pricing Availability   Qty
Description: Induces ferroptosis; inhibits FSP1
Chemical Name: 3-(4-Bromophenyl)-6-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)thiazolo[2,3-c][1,2,4]triazole
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)
Pathways (1)

Biological Activity for FSEN 1

FSEN 1 is a ferroptosis suppressor protein 1 (FSP1) inhibitor (IC50 = 313 nM). FSEN 1 sensitizes lung cancer cells and organoids to ferroptosis (EC50 = 69 nM) through inhibition of FSP1. Inhibits FSP1 CoQ1 oxidoreductase activity (IC50 = 688 nM).

Technical Data for FSEN 1

M. Wt 484.42
Formula C22H22BrN5OS
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 862808-01-3
PubChem ID 22583648
InChI Key JGXIXBKKDUNARN-UHFFFAOYSA-N
Smiles BrC1=CC=C(C2=NN=C3SC(CN4CCN(CC4)C5=CC=C(C=C5)OC)=CN32)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for FSEN 1

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.69 20

Preparing Stock Solutions for FSEN 1

The following data is based on the product molecular weight 484.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 10.32 mL 51.61 mL 103.22 mL
1 mM 2.06 mL 10.32 mL 20.64 mL
2 mM 1.03 mL 5.16 mL 10.32 mL
10 mM 0.21 mL 1.03 mL 2.06 mL

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References for FSEN 1

References are publications that support the biological activity of the product.

Hendricks et al (2023) Identification of structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis. Cell Chem.Biol. 30 1090 PMID: 37178691


If you know of a relevant reference for FSEN 1, please let us know.

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Keywords: FSEN 1, FSEN 1 supplier, FSEN1, ferroptosis, sensititizer, 1, suppressor, protein, FSP1, CoQ1, lung, cancer, Ferroptosis, 7941, Tocris Bioscience

Citations for FSEN 1

Citations are publications that use Tocris products.

Currently there are no citations for FSEN 1. Do you know of a great paper that uses FSEN 1 from Tocris? Please let us know.

Reviews for FSEN 1

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


MAPK Signaling Scientific Review

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Alzheimer's Disease Poster

Alzheimer's Disease Poster

Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.

Pathways for FSEN 1

MAPK Signaling Pathway

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.