You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Potent group I PAK inhibitor (IC50 values are 8, 13 and 19 nM for PAK1, 2 and 3, respectively). Exhibits significant inhibition of YES1, RET, CSF1R and TEK at 100 nM, but is inactive against group II PAK isoforms (IC50 >10 μM for PAK4). Inhibits proliferation of pancreatic cancer and schwannoma cells in vitro and exhibits antitumor effects in mice.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 558.1. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||8.96 mL||44.79 mL||89.59 mL|
|1 mM||1.79 mL||8.96 mL||17.92 mL|
|2 mM||0.9 mL||4.48 mL||8.96 mL|
|10 mM||0.18 mL||0.9 mL||1.79 mL|
References are publications that support the biological activity of the product.
Licciulli et al (2013) FRAX597, a small molecule inhibitor of the p21-activated kinases, inhibits tumorigenesis of neurofibromatosis type 2 (NF2)-associated Schwannomas. J.Biol.Chem. 288 29105 PMID: 23960073
Yeo et al (2016) FRAX597, a PAK1 inhibitor, synergistically reduces pancreatic cancer growth when combined with gemcit. BMC Cancer 16 24 PMID: 26774265
If you know of a relevant reference for FRAX 597, please let us know.
View Related Products by Product Action
Keywords: FRAX 597, FRAX 597 supplier, FRAX597, potent, group, I, PAK, inhibits, inhibitors, p21, activated, kinase, P21-activated, Kinases, 6029, Tocris Bioscience
Citations for FRAX 597
Citations are publications that use Tocris products.
Currently there are no citations for FRAX 597. Do you know of a great paper that uses FRAX 597 from Tocris? Please let us know.
Reviews for FRAX 597
There are currently no reviews for this product. Be the first to review FRAX 597 and earn rewards!
Have you used FRAX 597?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.