FPR A14

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Cat.No. 2826 - FPR A14 | C23H20N2O5 | CAS No. 329691-12-5
Description: FPR agonist
Chemical Name: 1,3-Benzodioxolane-5-carboxylic acid 4'-benzyloxy-3'-methoxybenzylidene hydrazide
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (1)

Biological Activity

Formyl peptide receptor (FPR) agonist that potently activates neutrophils in vitro (EC50 values are 42 and 630 nM for neutrophil chemotaxis and Ca2+ mobilization respectively). Induces dose-dependent differentiation of mouse neuroblastoma N2a cells.

Technical Data

M. Wt 404.42
Formula C23H20N2O5
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 329691-12-5
PubChem ID 5503194
InChI Key ULOKADSYVZOTTL-CFRMEGHHSA-N
Smiles O=C(N/N=C\C3=CC=C(OCC4=CC=CC=C4)C(OC)=C3)C1=CC(OCO2)=C2C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.44 100

Preparing Stock Solutions

The following data is based on the product molecular weight 404.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.47 mL 12.36 mL 24.73 mL
5 mM 0.49 mL 2.47 mL 4.95 mL
10 mM 0.25 mL 1.24 mL 2.47 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

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References

References are publications that support the biological activity of the product.

Schepetkin et al (2007) High-throughput screening for small molecule activators of neutrophils: Identification of novel N-formyl peptide receptor agonists. Mol.Pharmacol. 71 1061 PMID: 17229869

Cussell et al (2019) The formyl peptide receptor agonist FPRa14 induces differentiation of Neuro2a mouse neuroblastoma cells into multiple distinct morphologies which can be specifically inhibited with FPR antagonists and FPR knockdown using siRNA. PLoS One 14 e0217815 PMID: 31170199


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2 Citations for FPR A14

Citations are publications that use Tocris products. Selected citations for FPR A14 include:

Yan et al (2015) Stimulation of hepatocarcinogenesis by neutrophils upon induction of oncogenic kras expression in transgenic zebrafish. J Hepatol 63 420 PMID: 25828472

Cussell et al (2019) The formyl peptide receptor agonist FPRa14 induces differentiation of Neuro2a mouse neuroblastoma cells into multiple distinct morphologies which can be specifically inhibited with FPR antagonists and FPR knockdown using siRNA. PLoS One. 14 e0217815 PMID: 31170199


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Literature in this Area

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