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Description: Irreversible ribosomal S6 kinase 1/2 inhibitor
Chemical Name: 1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone
Purity: ≥97% (HPLC)

Biological Activity for Fmk

Fmk is a potent irreversible RSK1/2 inhibitor (IC50 = 15 nM). Inactivates the C-terminal auto-kinase domain activity. Suppresses RSK2 kinase activity in RSK2-expressing HNSCC cell lines. Reduces HNSCC cell invasive ability. Displays no effect on EGF-stimulated phosphorylation of ERK1 or ERK2.

Technical Data for Fmk

M. Wt 342.37
Formula C18H19FN4O2
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 821794-92-7
PubChem ID 644243
Smiles O=C(CF)C2=C(C3=CC=C(C)C=C3)C1=C(N)N=CN=C1N2CCCO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Fmk

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 34.24 100

Preparing Stock Solutions for Fmk

The following data is based on the product molecular weight 342.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.92 mL 14.6 mL 29.21 mL
5 mM 0.58 mL 2.92 mL 5.84 mL
10 mM 0.29 mL 1.46 mL 2.92 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

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References for Fmk

References are publications that support the biological activity of the product.

Cohen et al (2005) Structural bioinformatics-based design of selective, irreversible kinase inhibitors. Science 308 1318 PMID: 15919995

Cohen et al (2007) A clickable inhibitor reveals context-dependent autoactivation of p90 RSK. Nat.Chem.Biol. 3 156 PMID: 17259979

Kang et al (2010) p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells. J.Clin.Invest. 120 1165 PMID: 20234090

If you know of a relevant reference for Fmk, please let us know.

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Keywords: Fmk, Fmk supplier, RSK-FMK, Irreversible, RSK1, RSK2, inhibitors, inhibits, p90, ribosomal, protein, S6, kinases, potent, RSK, 4690, Tocris Bioscience

Citations for Fmk

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