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Fmk

Cat. No. 4690 Submit a Review Datasheet / COA / SDS

Discontinued Product

4690 has been discontinued.

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Description: Irreversible ribosomal S6 kinase 1/2 inhibitor
Chemical Name: 1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone
Purity: ≥97% (HPLC)
Datasheet
Citations
Reviews
Biological Activity Technical Data Datasheets References

Biological Activity for Fmk

Fmk is a potent irreversible RSK1/2 inhibitor (IC50 = 15 nM). Inactivates the C-terminal auto-kinase domain activity. Suppresses RSK2 kinase activity in RSK2-expressing HNSCC cell lines. Reduces HNSCC cell invasive ability. Displays no effect on EGF-stimulated phosphorylation of ERK1 or ERK2.

Technical Data for Fmk

M. Wt 342.37
Formula C18H19FN4O2
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 821794-92-7
PubChem ID 644243
InChI Key IKLGYJACVCXYIL-UHFFFAOYSA-N
Smiles O=C(CF)C2=C(C3=CC=C(C)C=C3)C1=C(N)N=CN=C1N2CCCO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Fmk

References are publications that support the biological activity of the product.

Cohen et al (2005) Structural bioinformatics-based design of selective, irreversible kinase inhibitors. Science 308 1318 PMID: 15919995

Cohen et al (2007) A clickable inhibitor reveals context-dependent autoactivation of p90 RSK. Nat.Chem.Biol. 3 156 PMID: 17259979

Kang et al (2010) p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells. J.Clin.Invest. 120 1165 PMID: 20234090

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Keywords: Fmk, Fmk supplier, RSK-FMK, Irreversible, RSK1, RSK2, inhibitors, inhibits, p90, ribosomal, protein, S6, kinases, potent, RSK, 4690, Tocris Bioscience

Citations for Fmk

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