Potent irreversible RSK1/2 inhibitor (IC50 = 15 nM). Inactivates the C-terminal auto-kinase domain activity. Suppresses RSK2 kinase activity in RSK2-expressing HNSCC cell lines. Reduces HNSCC cell invasive ability. Displays no effect on EGF-stimulated phosphorylation of ERK1 or ERK2.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 342.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.92 mL||14.6 mL||29.21 mL|
|5 mM||0.58 mL||2.92 mL||5.84 mL|
|10 mM||0.29 mL||1.46 mL||2.92 mL|
|50 mM||0.06 mL||0.29 mL||0.58 mL|
References are publications that support the biological activity of the product.
Cohen et al (2005) Structural bioinformatics-based design of selective, irreversible kinase inhibitors. Science 308 1318 PMID: 15919995
Cohen et al (2007) A clickable inhibitor reveals context-dependent autoactivation of p90 RSK. Nat.Chem.Biol. 3 156 PMID: 17259979
Kang et al (2010) p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells. J.Clin.Invest. 120 1165 PMID: 20234090
If you know of a relevant reference for Fmk, please let us know.
View Related Products by Product Action
Keywords: Fmk, Fmk supplier, RSK-FMK, Irreversible, RSK1, RSK2, inhibitors, inhibits, p90, ribosomal, protein, S6, kinases, potent, RSK, 4690, Tocris Bioscience
Citations for Fmk
Citations are publications that use Tocris products.
Currently there are no citations for Fmk. Do you know of a great paper that uses Fmk from Tocris? Please let us know.
Reviews for Fmk
There are currently no reviews for this product. Be the first to review Fmk and earn rewards!
Have you used Fmk?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.