Flupenthixol dihydrochloride

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Cat.No. 4057 - Flupenthixol dihydrochloride | C23H25F3N2OS.2HCl | CAS No. 2413-38-9
Description: Dopamine receptor antagonist
Chemical Name: 4-[3-[2-(Trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl]-1-piperazineethanol dihydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Literature

Biological Activity

Antipsychotic drug. Exhibits antagonistic activity at dopamine D1-5 receptors. Used in schizophrenia treatment.

Technical Data

M. Wt 507.44
Formula C23H25F3N2OS.2HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 2413-38-9
PubChem ID 17011
InChI Key IOVDQEIIMOZNNA-UHFFFAOYSA-N
Smiles Cl.Cl.OCCN1CCN(CCC=C2C3=CC(=CC=C3SC3=C2C=CC=C3)C(F)(F)F)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.37 50
water 50.74 100

Preparing Stock Solutions

The following data is based on the product molecular weight 507.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.97 mL 9.85 mL 19.71 mL
5 mM 0.39 mL 1.97 mL 3.94 mL
10 mM 0.2 mL 0.99 mL 1.97 mL
50 mM 0.04 mL 0.2 mL 0.39 mL

Molarity Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Peuch et al (1981) Pharmacological properties of new antipsychotic agents: Use of animal models. Neuropharmacology 20 1279 PMID: 6119637


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Keywords: Flupenthixol 2HCl dopamine receptor antagonist antipsychotic drug schizophrenia Non-selective Dopamine

3 Citations for Flupenthixol dihydrochloride

Citations are publications that use Tocris products. Selected citations for Flupenthixol dihydrochloride include:

Schulz et al (2012) First and second generation antipsychotics influence hippocampal gamma oscillations by interactions with 5-HT3 and D3 receptors. Br J Pharmacol 167 1480 PMID: 22817643

Regna et al (2016) A critical role for the Drosophila dopamine D1-like receptor Dop1R2 at the onset of metamorphosis. PLoS One 16 15 PMID: 27184815

FitzGerald et al (2014) A high through-put screen for small molecules modulating MCM2 phosphorylation identifies Ryuvidine as an inducer of the DNA damage response. PLoS One 9 e98891 PMID: 24902048


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Dopamine Receptors

Dopamine Receptors Scientific Review

Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.

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Schizophrenia

Schizophrenia Poster

Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster highlights the targets and pathways representing the most promising strategies to pursue for novel drug development.

Pathways for Flupenthixol dihydrochloride

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