Flupenthixol dihydrochloride

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Cat.No. 4057 - Flupenthixol dihydrochloride | C23H25F3N2OS.2HCl | CAS No. 2413-38-9
Description: Dopamine antagonist
Alternative Names: Flupentixol
Chemical Name: 4-[3-[2-(Trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl]-1-piperazineethanol dihydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Reviews
Literature (5)

Biological Activity

Antipsychotic drug. Exhibits antagonistic activity at dopamine D1-5 receptors. Used in schizophrenia treatment.

This compound is a mixture of E/Z isomers (ratio: 60:40).

Compound Libraries

Flupenthixol dihydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 507.44
Formula C23H25F3N2OS.2HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 2413-38-9
PubChem ID 17011
InChI Key IOVDQEIIMOZNNA-UHFFFAOYSA-N
Smiles Cl.Cl.OCCN1CCN(CCC=C2C3=CC(=CC=C3SC3=C2C=CC=C3)C(F)(F)F)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 50.74 100
DMSO 25.37 50

Preparing Stock Solutions

The following data is based on the product molecular weight 507.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.97 mL 9.85 mL 19.71 mL
5 mM 0.39 mL 1.97 mL 3.94 mL
10 mM 0.2 mL 0.99 mL 1.97 mL
50 mM 0.04 mL 0.2 mL 0.39 mL

Molarity Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Peuch et al (1981) Pharmacological properties of new antipsychotic agents: Use of animal models. Neuropharmacology 20 1279 PMID: 6119637


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Keywords: Flupenthixol dihydrochloride, Flupenthixol dihydrochloride supplier, Flupenthixol, 2HCl, dopamine, receptor, antagonist, antipsychotic, drug, schizophrenia, Flupentixol, Non-selective, Dopamine, 4057, Tocris Bioscience

3 Citations for Flupenthixol dihydrochloride

Citations are publications that use Tocris products. Selected citations for Flupenthixol dihydrochloride include:

FitzGerald et al (2014) A high through-put screen for small molecules modulating MCM2 phosphorylation identifies Ryuvidine as an inducer of the DNA damage response. PLoS One 9 e98891 PMID: 24902048

Schulz et al (2012) First and second generation antipsychotics influence hippocampal gamma oscillations by interactions with 5-HT3 and D3 receptors. Br J Pharmacol 167 1480 PMID: 22817643

Regna et al (2016) A critical role for the Drosophila DA D1-like receptor Dop1R2 at the onset of metamorphosis. PLoS One 16 15 PMID: 27184815


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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