Flupenthixol dihydrochloride

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Description: Dopamine antagonist
Alternative Names: Flupentixol
Chemical Name: 4-[3-[2-(Trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl]-1-piperazineethanol dihydrochloride
Purity: ≥99% (HPLC)
Citations (6)
Literature (2)

Biological Activity for Flupenthixol dihydrochloride

Flupenthixol dihydrochloride is an antipsychotic drug. Exhibits antagonistic activity at dopamine D1-5 receptors. Used in schizophrenia treatment.

This compound is a mixture of E/Z isomers (ratio: 60:40).

Compound Libraries for Flupenthixol dihydrochloride

Flupenthixol dihydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Flupenthixol dihydrochloride

M. Wt 507.44
Formula C23H25F3N2OS.2HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 2413-38-9
PubChem ID 17011
Smiles Cl.Cl.OCCN1CCN(CCC=C2C3=CC(=CC=C3SC3=C2C=CC=C3)C(F)(F)F)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Flupenthixol dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 50.74 100
DMSO 25.37 50

Preparing Stock Solutions for Flupenthixol dihydrochloride

The following data is based on the product molecular weight 507.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.97 mL 9.85 mL 19.71 mL
5 mM 0.39 mL 1.97 mL 3.94 mL
10 mM 0.2 mL 0.99 mL 1.97 mL
50 mM 0.04 mL 0.2 mL 0.39 mL

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Product Datasheets for Flupenthixol dihydrochloride

Certificate of Analysis / Product Datasheet
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References for Flupenthixol dihydrochloride

References are publications that support the biological activity of the product.

Peuch et al (1981) Pharmacological properties of new antipsychotic agents: Use of animal models. Neuropharmacology 20 1279 PMID: 6119637

If you know of a relevant reference for Flupenthixol dihydrochloride, please let us know.

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Keywords: Flupenthixol dihydrochloride, Flupenthixol dihydrochloride supplier, Flupenthixol, 2HCl, dopamine, receptor, antagonist, antipsychotic, drug, schizophrenia, Flupentixol, Non-selective, Dopamine, 4057, Tocris Bioscience

6 Citations for Flupenthixol dihydrochloride

Citations are publications that use Tocris products. Selected citations for Flupenthixol dihydrochloride include:

FitzGerald et al (2014) A high through-put screen for small molecules modulating MCM2 phosphorylation identifies Ryuvidine as an inducer of the DNA damage response. PLoS One 9 e98891 PMID: 24902048

Clive R et al (2021) Antidepressant drugs act by directly binding to TRKB neurotrophin receptors. Cell 184 1299-1313.e19 PMID: 33606976

Regna et al (2016) A critical role for the Drosophila DA D1-like receptor Dop1R2 at the onset of metamorphosis. PLoS One 16 15 PMID: 27184815

Nicole F et al (2013) Dopamine D2 receptor antagonism suppresses tau aggregation and neurotoxicity. Biol Psychiatry 73 464-71 PMID: 23140663

Do you know of a great paper that uses Flupenthixol dihydrochloride from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Dopamine Receptors Scientific Review

Dopamine Receptors Scientific Review

Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.