Fluorobexarotene

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Cat.No. 4064 - Fluorobexarotene | C24H27FO2 | CAS No. 1190848-23-7
Description: RXR agonist
Chemical Name: 2-Fluoro-4-[1-(5-,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid
Purity: ≥97% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

RXR agonist (Ki = 12 nM; EC50 = 43 nM at RXRα receptors). Displays similar RAR agonist activity to bexarotene; exhibits an apparent RXR binding affinity 75% greater than bexarotene.

Licensing Information

Manufactured and sold under license from Arizona State University - Patent Pending

Technical Data

M. Wt 366.47
Formula C24H27FO2
Storage Store at +4°C
Purity ≥97% (HPLC)
CAS Number 1190848-23-7
PubChem ID 25195496
InChI Key LWKAWHRSPCHMPJ-UHFFFAOYSA-N
Smiles CC(C(C(C3=CC=C(C(O)=O)C(F)=C3)=C)=C2)=CC1=C2C(C)(C)CCC(C)1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.65 100
ethanol 9.16 25

Preparing Stock Solutions

The following data is based on the product molecular weight 366.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.73 mL 13.64 mL 27.29 mL
5 mM 0.55 mL 2.73 mL 5.46 mL
10 mM 0.27 mL 1.36 mL 2.73 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the biological activity of the product.

Wagner et al (2009) Modeling, synthesis and biological evaluation of potential retinoid X receptor (RXR) selective agonists: novel analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene). J.Med.Chem. 52 5950 PMID: 19791803


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Citations for Fluorobexarotene

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Reviews for Fluorobexarotene

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