Fluorobexarotene

Discontinued Product

Fluorobexarotene (Cat. No. 4064) has been withdrawn from sale for commercial reasons.
Description: RXR agonist
Chemical Name: 2-Fluoro-4-[1-(5-,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid
Purity: ≥97% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity for Fluorobexarotene

Fluorobexarotene is a RXR agonist (Ki = 12 nM; EC50 = 43 nM at RXRα receptors). Displays similar RAR agonist activity to bexarotene; exhibits an apparent RXR binding affinity 75% greater than bexarotene.

Licensing Information

Manufactured and sold under license from Arizona State University - Patent Pending

Technical Data for Fluorobexarotene

M. Wt 366.47
Formula C24H27FO2
Storage Store at +4°C
Purity ≥97% (HPLC)
CAS Number 1190848-23-7
PubChem ID 25195496
InChI Key LWKAWHRSPCHMPJ-UHFFFAOYSA-N
Smiles CC(C(C(C3=CC=C(C(O)=O)C(F)=C3)=C)=C2)=CC1=C2C(C)(C)CCC(C)1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Fluorobexarotene

Certificate of Analysis / Product Datasheet
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References for Fluorobexarotene

References are publications that support the biological activity of the product.

Wagner et al (2009) Modeling, synthesis and biological evaluation of potential retinoid X receptor (RXR) selective agonists: novel analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene). J.Med.Chem. 52 5950 PMID: 19791803

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Citations for Fluorobexarotene

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Currently there are no citations for Fluorobexarotene.

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Literature in this Area

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