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Cat.No. 4659 - Floxuridine | C9H11FN2O5 | CAS No. 50-91-9
Description: Inhibitor of thymidylate synthetase; anticancer agent
Alternative Names: FdUrd
Chemical Name: 5-Fluoro-2'-deoxyuridine
Purity: ≥98% (HPLC)

Biological Activity

Antineoplastic antimetabolite. Exhibits antiproliferative activity; inhibits thymidylate synthetase and disrupts DNA replication in human cells. Induces double-strand DNA breaks; activates ATR and ATM signaling pathways. Induces phosphorylation of Chk1 and Chk2 in OVCAR-8 and SKOV3ip ovarian cancer cell lines.

Technical Data

M. Wt 246.19
Formula C9H11FN2O5
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 50-91-9
PubChem ID 5790
Smiles O[C@H]1C[C@H](N2C=C(F)C(NC2=O)=O)O[C@@H]1CO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 24.62 100
ethanol 24.62 100
water 24.62 100

Preparing Stock Solutions

The following data is based on the product molecular weight 246.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.06 mL 20.31 mL 40.62 mL
5 mM 0.81 mL 4.06 mL 8.12 mL
10 mM 0.41 mL 2.03 mL 4.06 mL
50 mM 0.08 mL 0.41 mL 0.81 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Huehls et al (2012) Poly(ADP-ribose) polymerase inhibition synergizes with 5-fluorodeoxyuridine but not 5-fluorouracil in ovarian cancer cells. Cancer Res. 71 4944 PMID: 21613406

Bapat et al (1983) Human leukemic cells resistant to 5-fluoro-2'-deoxyuridine contain a thymidylate synthetase with lower affinity for nucleotides. J.Biol.Chem. 258 4130 PMID: 6220000

Wyatt and Wilson (2009) Participation of DNA repair in the response to 5-fluorouracil. Cell.Mol.Life Sci. 66 788 PMID: 18979208

If you know of a relevant reference for Floxuridine, please let us know.

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Keywords: FdUrd antiproliferatives antineoplastic antimetabolites thymidylate synthetases synthases inhibititors DNA synthesis antimetabolites chemotherapeutics FdUrd Other Synthases/Synthetases

Citations for Floxuridine

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Literature in this Area


Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pathways for Floxuridine


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