Floxuridine

Pricing Availability Delivery Time Qty
Cat.No. 4659 - Floxuridine | C9H11FN2O5 | CAS No. 50-91-9
Description: Inhibitor of thymidylate synthetase; anticancer agent
Alternative Names: FdUrd
Chemical Name: 5-Fluoro-2'-deoxyuridine
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Antineoplastic antimetabolite. Exhibits antiproliferative activity; inhibits thymidylate synthetase and disrupts DNA replication in human cells. Induces double-strand DNA breaks; activates ATR and ATM signaling pathways. Induces phosphorylation of Chk1 and Chk2 in OVCAR-8 and SKOV3ip ovarian cancer cell lines.

Technical Data

M. Wt 246.19
Formula C9H11FN2O5
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 50-91-9
PubChem ID 5790
InChI Key ODKNJVUHOIMIIZ-RRKCRQDMSA-N
Smiles O[C@H]1C[C@H](N2C=C(F)C(NC2=O)=O)O[C@@H]1CO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 24.62 100
ethanol 24.62 100
water 24.62 100

Preparing Stock Solutions

The following data is based on the product molecular weight 246.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.06 mL 20.31 mL 40.62 mL
5 mM 0.81 mL 4.06 mL 8.12 mL
10 mM 0.41 mL 2.03 mL 4.06 mL
50 mM 0.08 mL 0.41 mL 0.81 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Huehls et al (2012) Poly(ADP-ribose) polymerase inhibition synergizes with 5-fluorodeoxyuridine but not 5-fluorouracil in ovarian cancer cells. Cancer Res. 71 4944 PMID: 21613406

Bapat et al (1983) Human leukemic cells resistant to 5-fluoro-2'-deoxyuridine contain a thymidylate synthetase with lower affinity for nucleotides. J.Biol.Chem. 258 4130 PMID: 6220000

Wyatt and Wilson (2009) Participation of DNA repair in the response to 5-fluorouracil. Cell.Mol.Life Sci. 66 788 PMID: 18979208


If you know of a relevant reference for Floxuridine, please let us know.

View Related Products by Product Action

View all Other Synthase/Synthetase Inhibitors

Keywords: FdUrd antiproliferatives antineoplastic antimetabolites thymidylate synthetases synthases inhibititors DNA synthesis antimetabolites chemotherapeutics FdUrd Other Synthases/Synthetases

Citations for Floxuridine

Citations are publications that use Tocris products.

Currently there are no citations for Floxuridine. Do you know of a great paper that uses Floxuridine from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pathways for Floxuridine

Protocols

TODO: Add Protocols