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Submit ReviewFloxuridine
Description: Thymidylate synthetase inhibitor
Alternative Names: FdUrd
Chemical Name: 5-Fluoro-2'-deoxyuridine
Purity: ≥98% (HPLC)
Biological Activity for Floxuridine
Floxuridine is an antineoplastic antimetabolite. Exhibits antiproliferative activity; inhibits thymidylate synthetase and disrupts DNA replication in human cells. Induces double-strand DNA breaks; activates ATR and ATM signaling pathways. Induces phosphorylation of Chk1 and Chk2 in OVCAR-8 and SKOV3ip ovarian cancer cell lines.
Technical Data for Floxuridine
| M. Wt | 246.19 |
| Formula | C9H11FN2O5 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 50-91-9 |
| PubChem ID | 5790 |
| InChI Key | ODKNJVUHOIMIIZ-RRKCRQDMSA-N |
| Smiles | O[C@H]1C[C@H](N2C=C(F)C(NC2=O)=O)O[C@@H]1CO |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Floxuridine
References for Floxuridine
References are publications that support the biological activity of the product.
Huehls et al (2012) Poly(ADP-ribose) polymerase inhibition synergizes with 5-fluorodeoxyuridine but not 5-fluorouracil in ovarian cancer cells. Cancer Res. 71 4944 PMID: 21613406
Bapat et al (1983) Human leukemic cells resistant to 5-fluoro-2'-deoxyuridine contain a thymidylate synthetase with lower affinity for nucleotides. J.Biol.Chem. 258 4130 PMID: 6220000
Wyatt and Wilson (2009) Participation of DNA repair in the response to 5-fluorouracil. Cell.Mol.Life Sci. 66 788 PMID: 18979208
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1 Citation for Floxuridine
Citations are publications that use Tocris products. Selected citations for Floxuridine include:
Tiwari et al (2017) Zika virus infection reprograms global transcription of host cells to allow sustained infection. Emerg Microbes Infect 6 e24 PMID: 28442752
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
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Pathways for Floxuridine
Apoptosis Signaling Pathway
Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.