FLI 06

Cat. No. 5172 Submit a Review Datasheet / COA / SDS

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Cat.No. 5172 - FLI 06 | C25H30N2O5 | CAS No. 313967-18-9

Description: Inhibitor of Notch signaling

Chemical Name: Cyclohexyl 1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylate

Purity: ≥99% (HPLC)

Datasheet

Citations

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Literature

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Inhibitor of Notch signaling (EC₅₀ = 2.3 μM). Disrupts Notch trafficking and processing. Reduces amyloid β secretion. Changes the maturation and abolishes shredding of APP. Inhibits ER exporting and converts tubular ER to sheets.

Compound Libraries

FLI 06 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	438.52
Formula	C₂₅H₃₀N₂O₅
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	313967-18-9
PubChem ID	3103157
InChI Key	SWWVFYHSSOWZMF-UHFFFAOYSA-N
Smiles	O=C(OC3CCCCC3)C1=C(C)NC(CC(C)(C)CC4=O)=C4C1C2=CC=C([N+]([O-])=O)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	43.85	100
	ethanol	8.77	20

Preparing Stock Solutions

The following data is based on the product molecular weight 438.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.28 mL	11.4 mL	22.8 mL
5 mM	0.46 mL	2.28 mL	4.56 mL
10 mM	0.23 mL	1.14 mL	2.28 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the biological activity of the product.

Krämer et al (2013) Small molecules intercept Notch signaling and the early secretory pathway. Nat.Chem.Biol. 9 731 PMID: 24077179

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Keywords: FLI 06, FLI 06 supplier, FLI06, inhibitors, inhibits, Notch, signalling, amyloid, μ, beta, Translocation,, Exocytosis, &, Endocytosis, 5172, Tocris Bioscience

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Literature in this Area

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Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

Cancer Metabolism
Epigenetics in Cancer
Receptor Signaling
Cell Cycle and DNA Damage Repair
Angiogenesis
Invasion and Metastasis