FLI 06

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Cat.No. 5172 - FLI 06 | C25H30N2O5 | CAS No. 313967-18-9
Description: Inhibitor of Notch signaling; disrupts Notch trafficking and processing
Chemical Name: Cyclohexyl 1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylate
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

Inhibitor of Notch signaling (EC50 = 2.3 μM). Disrupts Notch trafficking and processing. Reduces amyloid β secretion. Changes the maturation and abolishes shredding of APP. Inhibits ER exporting and converts tubular ER to sheets.

Technical Data

M. Wt 438.52
Formula C25H30N2O5
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 313967-18-9
PubChem ID 3103157
InChI Key SWWVFYHSSOWZMF-UHFFFAOYSA-N
Smiles O=C(OC3CCCCC3)C1=C(C)NC(CC(C)(C)CC4=O)=C4C1C2=CC=C([N+]([O-])=O)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.85 100
ethanol 8.77 20

Preparing Stock Solutions

The following data is based on the product molecular weight 438.52. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.28 mL 11.4 mL 22.8 mL
5 mM 0.46 mL 2.28 mL 4.56 mL
10 mM 0.23 mL 1.14 mL 2.28 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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References

References are publications that support the biological activity of the product.

Krämer et al (2013) Small molecules intercept Notch signaling and the early secretory pathway. Nat.Chem.Biol. 9 731 PMID: 24077179


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Keywords: FLI 06, FLI 06 supplier, FLI06, inhibitors, inhibits, Notch, signalling, amyloid, μ, beta, Translocation,, Exocytosis, &, Endocytosis, Other, Signaling, Translocation, 5172, Tocris Bioscience

Citations for FLI 06

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