Inhibitor of Notch signaling (EC50 = 2.3 μM). Disrupts Notch trafficking and processing. Reduces amyloid β secretion. Changes the maturation and abolishes shredding of APP. Inhibits ER exporting and converts tubular ER to sheets.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 438.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.28 mL||11.4 mL||22.8 mL|
|5 mM||0.46 mL||2.28 mL||4.56 mL|
|10 mM||0.23 mL||1.14 mL||2.28 mL|
|50 mM||0.05 mL||0.23 mL||0.46 mL|
References are publications that support the products' biological activity.
Krämer et al (2013) Small molecules intercept Notch signaling and the early secretory pathway. Nat.Chem.Biol. 9 731 PMID: 24077179
If you know of a relevant reference for FLI 06, please let us know.
Keywords: FLI 06, supplier, FLI06, inhibitors, inhibits, Notch, signalling, amyloid, μ, beta, Translocation,, Exocytosis, &, Endocytosis, Translocation,, Exocytosis, &, Endocytosis, Tocris Bioscience
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