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Biological Activity for Flavopiridol hydrochloride
Flavopiridol hydrochloride is a cyclin-dependent kinase (cdk) inhibitor (reported IC50 values are 6 - 25 nM and 84 - 200 nM for cdk9 and cdk2, respectively, and <0.85 μM for cdk1, cdk4, cdk5 and cdk7). Induces cell cycle arrest at G1 and G2 phase. Potently inhibits the growth of breast and lung cancer cell lines (IC50 = 25 - 160 nM) in vitro.
Compound Libraries for Flavopiridol hydrochloride
Technical Data for Flavopiridol hydrochloride
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Flavopiridol hydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Flavopiridol hydrochloride
The following data is based on the product molecular weight 438.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.28 mL||11.41 mL||22.82 mL|
|5 mM||0.46 mL||2.28 mL||4.56 mL|
|10 mM||0.23 mL||1.14 mL||2.28 mL|
|50 mM||0.05 mL||0.23 mL||0.46 mL|
Product Datasheets for Flavopiridol hydrochloride
References for Flavopiridol hydrochloride
References are publications that support the biological activity of the product.
Kaur et al (1992) Growth inhibition with reversible cell cycle arrest of carcinoma cells by Flavone L86-8275. J.Natl.Cancer.Inst. 84 1736 PMID: 1279187
Ambrosini et al (2008) The cyclin-dependent kinase inhibitor flavopiridol potentiates the effects of topoisomerase I poisons by suppressing Rad51 expression in a p53-dependent manner. Cancer Res. 68 2312 PMID: 18381438
Losiewicz et al (1994) Potent inhibition of Cdc2 kinase activity by the flavonoid L86-8275. Biochem.Biophys.Res.Comm. 201 589
Jorda et al (2018) How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 61 9105 PMID: 30234987
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1 Citation for Flavopiridol hydrochloride
Citations are publications that use Tocris products. Selected citations for Flavopiridol hydrochloride include:
Stork et al (2016) Co-transcriptional R-loops are the main cause of estrogen-induced DNA damage. Elife 5 PMID: 27552054
Do you know of a great paper that uses Flavopiridol hydrochloride from Tocris? Please let us know.
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