FK 3311

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Cat.No. 2776 - FK 3311 | C15H13F2NO4S | CAS No. 116686-15-8
Description: Cyclooxygenase-2 (COX-2) inhibitor
Chemical Name: N-[4-Acetyl-2-(2,4-difluorophenoxy)phenyl]methanesulfonamide
Purity: ≥98% (HPLC)
Literature (7)

Biological Activity

Cyclooxygenase-2 (COX-2) inhibitor. Inhibits zymosan-induced prostaglandin E2 production by rat peritoneal neutrophils in vitro and adjuvant-induced arthritis in vivo. Anti-inflammatory.

Technical Data

M. Wt 341.33
Formula C15H13F2NO4S
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 116686-15-8
PubChem ID 164009
Smiles FC1=CC(F)=CC=C1OC2=C(NS(=O)(C)=O)C=CC(C(C)=O)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 34.13 100
ethanol 17.07 50

Preparing Stock Solutions

The following data is based on the product molecular weight 341.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.93 mL 14.65 mL 29.3 mL
5 mM 0.59 mL 2.93 mL 5.86 mL
10 mM 0.29 mL 1.46 mL 2.93 mL
50 mM 0.06 mL 0.29 mL 0.59 mL

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References are publications that support the biological activity of the product.

Tsuji et al (1992) Studies on antiinflammatory agents. I. Synthesis and pharmacological properties of 2'-phenoxy-methanesulfonanilide derivatives. Chem.Pharm.Bull. 40 2399 PMID: 1446362

Otani et al (2007) Effects of the COX-2 inhibitor FK3311 on ischemia-reperfusion injury in the rat lung. J.Invest.Surg. 20 175 PMID: 17613692

Nakamura et al (1993) Studies on antiinflammatory agents. III. Synthesis and pharmacological properties of metabolites of 4'-acetyl-2'-(2,4-difluorophenoxy)methanesulfonanilide (FK3311). Chem.Pharm.Bull. 41

If you know of a relevant reference for FK 3311, please let us know.

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Keywords: FK 3311, FK 3311 supplier, Cyclooxygenase-2, COX-2, inhibitors, inhibits, Oxygenases, Oxidases, FK3311, Cyclooxygenase, 2776, Tocris Bioscience

Citations for FK 3311

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