FIT

Discontinued Product

FIT (Cat. No. 1480) has been withdrawn from sale for commercial reasons.
Cat.No. 1480 - FIT | C23H27N3OS | CAS No. 85951-63-9
Description: Irreversible δ agonist
Alternative Names: Fentanyl isothiocyanate
Chemical Name: N-[1-[2-(4-Isothiocyanatophenyl)ethyl]-4-piperidinyl]-N-phenylpropanamide
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Selective and irreversible δ-opioid agonist (EC50 = 8 nM); acts by alkylating the receptor.

Technical Data

M. Wt 393.55
Formula C23H27N3OS
Storage Desiccate at -20°C
Purity ≥99% (HPLC)
CAS Number 85951-63-9
PubChem ID 84008
InChI Key VDKBIFPJULZUPU-UHFFFAOYSA-N
Smiles CCC(=O)N(C1CCN(CCC2=CC=C(C=C2)N=C=S)CC1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Rice et al (1983) Irreversible ligands with high selectivity toward δ or μ opiate receptors. Science 220 314 PMID: 6132444

Rothman et al (1985) Evidence that the delta-selective alkylating agent, fit, alters the mu-noncompetitive opiate delta binding site. Neuropeptides 6 227 PMID: 2991807

Schoffelmeer et al (1988) μ-, δ- and κ-opioid receptor-mediated inhibition of neurotransmitter release and adenylate cyclase activity in rat brain slices: studies with fen. isothiocyanate. Eur.J.Pharmacol. 154 169 PMID: 2906610

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Keywords: FIT, FIT supplier, Irreversible, δ-opioid, delta-opioid, agonists, DOP, Receptors, OP1, Fentanyl, isothiocyanate, Delta, Opioid, 1480, Tocris Bioscience

1 Citation for FIT

Citations are publications that use Tocris products. Selected citations for FIT include:

Gross et al (2006) The JAK/STAT pathway is essential for opioid-induced cardioprotection: JAK2 as a mediator of STAT3, Akt, and GSK-3 beta. Am J Physiol Heart Circ Physiol 291 H827 PMID: 16517948


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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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