Discontinued Product

FIT (Cat. No. 1480) has been withdrawn from sale for commercial reasons.
Description: Irreversible δ agonist
Alternative Names: Fentanyl isothiocyanate
Chemical Name: N-[1-[2-(4-Isothiocyanatophenyl)ethyl]-4-piperidinyl]-N-phenylpropanamide
Purity: ≥99% (HPLC)
Citations (1)
Literature (2)

Biological Activity for FIT

Selective and irreversible δ-opioid agonist (EC50 = 8 nM); acts by alkylating the receptor.

Technical Data for FIT

M. Wt 393.55
Formula C23H27N3OS
Storage Desiccate at -20°C
Purity ≥99% (HPLC)
CAS Number 85951-63-9
PubChem ID 84008
Smiles CCC(=O)N(C1CCN(CCC2=CC=C(C=C2)N=C=S)CC1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for FIT

Certificate of Analysis / Product Datasheet
Select another batch:

References for FIT

References are publications that support the biological activity of the product.

Rice et al (1983) Irreversible ligands with high selectivity toward δ or μ opiate receptors. Science 220 314 PMID: 6132444

Rothman et al (1985) Evidence that the delta-selective alkylating agent, fit, alters the mu-noncompetitive opiate delta binding site. Neuropeptides 6 227 PMID: 2991807

Schoffelmeer et al (1988) μ-, δ- and κ-opioid receptor-mediated inhibition of neurotransmitter release and adenylate cyclase activity in rat brain slices: studies with fen. isothiocyanate. Eur.J.Pharmacol. 154 169 PMID: 2906610

View Related Products by Target

View Related Products by Product Action

View all δ Opioid Receptor Agonists

Keywords: FIT, FIT supplier, Irreversible, δ-opioid, delta-opioid, agonists, DOP, Receptors, OP1, Fentanyl, isothiocyanate, Delta, Opioid, 1480, Tocris Bioscience

1 Citation for FIT

Citations are publications that use Tocris products. Selected citations for FIT include:

Gross et al (2006) The JAK/STAT pathway is essential for opioid-induced cardioprotection: JAK2 as a mediator of STAT3, Akt, and GSK-3 beta. Am J Physiol Heart Circ Physiol 291 H827 PMID: 16517948

Reviews for FIT

There are currently no reviews for this product. Be the first to review FIT and earn rewards!

Have you used FIT?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.