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Biological Activity for FIT
Selective and irreversible δ-opioid agonist (EC50 = 8 nM); acts by alkylating the receptor.
Technical Data for FIT
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References for FIT
References are publications that support the biological activity of the product.
Rice et al (1983) Irreversible ligands with high selectivity toward δ or μ opiate receptors. Science 220 314 PMID: 6132444
Rothman et al (1985) Evidence that the delta-selective alkylating agent, fit, alters the mu-noncompetitive opiate delta binding site. Neuropeptides 6 227 PMID: 2991807
Schoffelmeer et al (1988) μ-, δ- and κ-opioid receptor-mediated inhibition of neurotransmitter release and adenylate cyclase activity in rat brain slices: studies with fen. isothiocyanate. Eur.J.Pharmacol. 154 169 PMID: 2906610
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Keywords: FIT, FIT supplier, Irreversible, δ-opioid, delta-opioid, agonists, DOP, Receptors, OP1, Fentanyl, isothiocyanate, Delta, Opioid, 1480, Tocris Bioscience
1 Citation for FIT
Citations are publications that use Tocris products. Selected citations for FIT include:
Gross et al (2006) The JAK/STAT pathway is essential for opioid-induced cardioprotection: JAK2 as a mediator of STAT3, Akt, and GSK-3 beta. Am J Physiol Heart Circ Physiol 291 H827 PMID: 16517948
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.