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Potent phosholipase D (PLD) inhibitor (IC50 values are 20 and 25 nM for PLD2 and PLD1 respectively). Ameliorates PLD2-driven suppression of membrane ruffling and cell spreading. Orally available.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 457.93. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.37 mL||21.84 mL||43.67 mL|
|2.5 mM||0.87 mL||4.37 mL||8.73 mL|
|5 mM||0.44 mL||2.18 mL||4.37 mL|
|25 mM||0.09 mL||0.44 mL||0.87 mL|
References are publications that support the biological activity of the product.
Monovich et al (2007) Optimization of halopemide for phospholipase D2 inhibition. Bioorg.Med.Chem.Lett. 17 2310 PMID: 17317170
Su et al (2009) 5-fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis. Mol.Pharmcol. 75 43
If you know of a relevant reference for FIPI, please let us know.
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Keywords: FIPI, FIPI supplier, potent, phospholipases, D, PLD1, PLD2, inhibitors, inhibits, esterases, Phospholipases, 3600, Tocris Bioscience
5 Citations for FIPI
Citations are publications that use Tocris products. Selected citations for FIPI include:
Wang et al (2016) The prostaglandin E2-EP3 receptor axis regulates Anaplasma phagocytophilum-mediated NLRC4 inflammasome activation. PLoS Pathog. 12 e1005803 PMID: 27482714
Pastor et al (2014) Analysis of ECs and related compounds in plasma: artifactual isomerization and ex vivo enzymatic generation of 2-MGs. J Lipid Res 55 966 PMID: 24610889
Lin and Liu (2019) Mechanical Stretch Induces mTOR Recruitment and Activation at the Phosphatidic Acid-Enriched Macropinosome in Muscle Cell. Front Cell Dev Biol 7 78 PMID: 31139627
Pitt et al (2017) Neuroprotective astrocyte-derived Ins/IGF-1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers. Mol Biol Cell 28 2623 PMID: 28963439
Bonnefond et al (2015) Calcium signals inhibition sensitizes ovarian carcinoma cells to anti-Bcl-xL strategies through Mcl-1 down-regulation. Int J Mol Sci 20 535 PMID: 25627260
Do you know of a great paper that uses FIPI from Tocris? Please let us know.
Reviews for FIPI
Average Rating: 5 (Based on 2 Reviews.)
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100 μM treat 45min
Pretreat mouse macrophage cells with this inhibitor prior to the bacterial stimulation.
Literature in this Area
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