FIPI

Pricing Availability   Qty
Description: Phospholipase D inhibitor
Chemical Name: N-[2-[4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethy]-5-fluoro-1H-indole-2-carboxamide hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (7)
Reviews (2)

Biological Activity for FIPI

FIPI is a potent phosholipase D (PLD) inhibitor (IC50 values are 20 and 25 nM for PLD2 and PLD1 respectively). Ameliorates PLD2-driven suppression of membrane ruffling and cell spreading. Orally available.

Compound Libraries for FIPI

FIPI is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for FIPI

M. Wt 457.93
Formula C23H24FN5O2.HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1781834-93-2
PubChem ID 90488864
InChI Key BNMQCDOCYPGJJD-UHFFFAOYSA-N
Smiles O=C(N2)N(C3CCN(CCNC(C4=CC5=C(C=CC(F)=C5)N4)=O)CC3)C1=C2C=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for FIPI

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.9 50

Preparing Stock Solutions for FIPI

The following data is based on the product molecular weight 457.93. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.37 mL 21.84 mL 43.67 mL
2.5 mM 0.87 mL 4.37 mL 8.73 mL
5 mM 0.44 mL 2.18 mL 4.37 mL
25 mM 0.09 mL 0.44 mL 0.87 mL

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Product Datasheets for FIPI

Certificate of Analysis / Product Datasheet
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References for FIPI

References are publications that support the biological activity of the product.

Monovich et al (2007) Optimization of halopemide for phospholipase D2 inhibition. Bioorg.Med.Chem.Lett. 17 2310 PMID: 17317170

Su et al (2009) 5-fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis. Mol.Pharmcol. 75 43


If you know of a relevant reference for FIPI, please let us know.

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Keywords: FIPI, FIPI supplier, potent, phospholipases, D, PLD1, PLD2, inhibitors, inhibits, esterases, Phospholipases, 3600, Tocris Bioscience

Reviews for FIPI

Average Rating: 5 (Based on 2 Reviews.)

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great product.
By Anonymous on 03/26/2020
Assay Type: In Vitro
Species: Rat
Cell Line/Tissue: Hippocampal neuron

100 μM treat 45min

review image

used this drug as an inhibitor.
By Anonymous on 10/05/2017
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: macrophages

Pretreat mouse macrophage cells with this inhibitor prior to the bacterial stimulation.

PMID: 27482714
review image