Fexofenadine hydrochloride

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Cat.No. 2429 - Fexofenadine hydrochloride | C32H39NO4.HCl | CAS No. 153439-40-8
Description: H1 receptor antagonist; non-sedating antiallergic agent
Alternative Names: MDL 16455, Terfenidine
Chemical Name: α,α-Dimethyl-4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-benzeneacetic acid hydrochloride
Purity: ≥99% (HPLC)
Citations (1)

Biological Activity

Selective histamine H1 receptor antagonist (pKi = 8.1). Active metabolite of terfenadine that displays non-sedating antiallergic effects.

Compound Libraries

Fexofenadine hydrochloride is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 538.12
Formula C32H39NO4.HCl
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 153439-40-8
PubChem ID 63002
Smiles Cl.CC(C)(C(O)=O)C1=CC=C(C=C1)C(O)CCCN1CCC(CC1)C(O)(C1=CC=CC=C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 26.9 50

Preparing Stock Solutions

The following data is based on the product molecular weight 538.12. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.86 mL 9.29 mL 18.58 mL
5 mM 0.37 mL 1.86 mL 3.72 mL
10 mM 0.19 mL 0.93 mL 1.86 mL
50 mM 0.04 mL 0.19 mL 0.37 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Markham and Wagstaff (1998) Fexofenadine. Drugs 55 269 PMID: 9506246

Sakairi et al (2005) Effects of fexofenadine hydrochloride in a guinea pig model of antigen-induced rhinitis. Pharmacology 75 76 PMID: 16037679

Gillard and Chatelaine (2006) Changes in pH differently affect the binding properties of histamine H1 receptor antagonists. Eur.J.Pharmacol. 530 205 PMID: 16388798

If you know of a relevant reference for Fexofenadine hydrochloride, please let us know.

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Keywords: Fexofenadine hydrochloride, supplier, H1, receptor, antagonists, non-sedating, antiallergic, agent, Receptors, Histamine, histaminergic, MDL16455, MDL, 16455, Terfenidine, Histamine, H1, Receptors, Histamine, H1, Receptors, Tocris Bioscience

1 Citation for Fexofenadine hydrochloride

Citations are publications that use Tocris products. Selected citations for Fexofenadine hydrochloride include:

Won et al (2013) A modified grapefruit juice eliminates two compound classes as major mediators of the grapefruit juice-fexofenadine interaction: an in vitro-in vivo " connect". Mucosal Immunol 53 982 PMID: 23878024

Do you know of a great paper that uses Fexofenadine hydrochloride from Tocris? If so please let us know.

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