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Selective histamine H1 receptor antagonist (pKi = 8.1). Active metabolite of terfenadine that displays non-sedating antiallergic effects.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 538.12. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||3.72 mL||18.58 mL||37.17 mL|
|2.5 mM||0.74 mL||3.72 mL||7.43 mL|
|5 mM||0.37 mL||1.86 mL||3.72 mL|
|25 mM||0.07 mL||0.37 mL||0.74 mL|
References are publications that support the biological activity of the product.
Markham and Wagstaff (1998) Fexofenadine. Drugs 55 269 PMID: 9506246
Sakairi et al (2005) Effects of fexofenadine hydrochloride in a guinea pig model of antigen-induced rhinitis. Pharmacology 75 76 PMID: 16037679
Gillard and Chatelaine (2006) Changes in pH differently affect the binding properties of histamine H1 receptor antagonists. Eur.J.Pharmacol. 530 205 PMID: 16388798
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Keywords: Fexofenadine hydrochloride, Fexofenadine hydrochloride supplier, H1, receptor, antagonists, non-sedating, antiallergic, agent, Receptors, Histamine, histaminergic, MDL16455, MDL, 16455, Terfenidine, 2429, Tocris Bioscience
1 Citation for Fexofenadine hydrochloride
Citations are publications that use Tocris products. Selected citations for Fexofenadine hydrochloride include:
Won et al (2013) A modified grapefruit juice eliminates two compound classes as major mediators of the grapefruit juice-fexofenadine interaction: an in vitro-in vivo " connect". Mucosal Immunol 53 982 PMID: 23878024
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