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Submit ReviewFexofenadine hydrochloride
Discontinued Product
Fexofenadine hydrochloride (Cat. No. 2429) has been withdrawn from sale for commercial reasons.
Description: H1 receptor antagonist; non-sedating antiallergic agent
Alternative Names: MDL 16455, Terfenidine
Chemical Name: α,α-Dimethyl-4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-benzeneacetic acid hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Fexofenadine hydrochloride
Fexofenadine hydrochloride is a selective histamine H1 receptor antagonist (pKi = 8.1). Active metabolite of Terfenadine (Cat. No. 3948) that displays non-sedating antiallergic effects. Fexofenadine hydrochloride counteracts histamine mediated immune suppression and improves immunotherapy response.
Compound Libraries for Fexofenadine hydrochloride
Fexofenadine hydrochloride is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
Technical Data for Fexofenadine hydrochloride
| M. Wt | 538.12 |
| Formula | C32H39NO4.HCl |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 153439-40-8 |
| PubChem ID | 63002 |
| InChI Key | RRJFVPUCXDGFJB-UHFFFAOYSA-N |
| Smiles | Cl.CC(C)(C(O)=O)C1=CC=C(C=C1)C(O)CCCN1CCC(CC1)C(O)(C1=CC=CC=C1)C1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Fexofenadine hydrochloride
References for Fexofenadine hydrochloride
References are publications that support the biological activity of the product.
Markham and Wagstaff (1998) Fexofenadine. Drugs 55 269 PMID: 9506246
Sakairi et al (2005) Effects of fexofenadine hydrochloride in a guinea pig model of antigen-induced rhinitis. Pharmacology 75 76 PMID: 16037679
Gillard and Chatelaine (2006) Changes in pH differently affect the binding properties of histamine H1 receptor antagonists. Eur.J.Pharmacol. 530 205 PMID: 16388798
Li et al (2022) The allergy mediator histamine confers resistance to immunotherapy in cancer patients via activation of the macrophage histamine receptor H1. Cancer Cell 40 36 PMID: 34822775
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Keywords: Fexofenadine hydrochloride, Fexofenadine hydrochloride supplier, H1, receptor, antagonists, non-sedating, antiallergic, agent, Receptors, Histamine, histaminergic, MDL16455, MDL, 16455, Terfenidine, 2429, Tocris Bioscience
1 Citation for Fexofenadine hydrochloride
Citations are publications that use Tocris products. Selected citations for Fexofenadine hydrochloride include:
Won et al (2013) A modified grapefruit juice eliminates two compound classes as major mediators of the grapefruit juice-fexofenadine interaction: an in vitro-in vivo " connect". Mucosal Immunol 53 982 PMID: 23878024
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Histamine Receptors Scientific Review
Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.