Fexofenadine hydrochloride

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Description: H1 receptor antagonist; non-sedating antiallergic agent
Alternative Names: MDL 16455, Terfenidine
Chemical Name: α,α-Dimethyl-4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-benzeneacetic acid hydrochloride
Purity: ≥99% (HPLC)
Citations (1)
Literature (2)

Biological Activity for Fexofenadine hydrochloride

Fexofenadine hydrochloride is a selective histamine H1 receptor antagonist (pKi = 8.1). Active metabolite of Terfenadine (Cat. No. 3948) that displays non-sedating antiallergic effects. Fexofenadine hydrochloride counteracts histamine mediated immune suppression and improves immunotherapy response.

Compound Libraries for Fexofenadine hydrochloride

Fexofenadine hydrochloride is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Fexofenadine hydrochloride

M. Wt 538.12
Formula C32H39NO4.HCl
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 153439-40-8
PubChem ID 63002
Smiles Cl.CC(C)(C(O)=O)C1=CC=C(C=C1)C(O)CCCN1CCC(CC1)C(O)(C1=CC=CC=C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Fexofenadine hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 26.9 50

Preparing Stock Solutions for Fexofenadine hydrochloride

The following data is based on the product molecular weight 538.12. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.72 mL 18.58 mL 37.17 mL
2.5 mM 0.74 mL 3.72 mL 7.43 mL
5 mM 0.37 mL 1.86 mL 3.72 mL
25 mM 0.07 mL 0.37 mL 0.74 mL

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Product Datasheets for Fexofenadine hydrochloride

References for Fexofenadine hydrochloride

References are publications that support the biological activity of the product.

Markham and Wagstaff (1998) Fexofenadine. Drugs 55 269 PMID: 9506246

Sakairi et al (2005) Effects of fexofenadine hydrochloride in a guinea pig model of antigen-induced rhinitis. Pharmacology 75 76 PMID: 16037679

Gillard and Chatelaine (2006) Changes in pH differently affect the binding properties of histamine H1 receptor antagonists. Eur.J.Pharmacol. 530 205 PMID: 16388798

Li et al (2022) The allergy mediator histamine confers resistance to immunotherapy in cancer patients via activation of the macrophage histamine receptor H1. Cancer Cell 40 36 PMID: 34822775

If you know of a relevant reference for Fexofenadine hydrochloride, please let us know.

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Keywords: Fexofenadine hydrochloride, Fexofenadine hydrochloride supplier, H1, receptor, antagonists, non-sedating, antiallergic, agent, Receptors, Histamine, histaminergic, MDL16455, MDL, 16455, Terfenidine, 2429, Tocris Bioscience

1 Citation for Fexofenadine hydrochloride

Citations are publications that use Tocris products. Selected citations for Fexofenadine hydrochloride include:

Won et al (2013) A modified grapefruit juice eliminates two compound classes as major mediators of the grapefruit juice-fexofenadine interaction: an in vitro-in vivo " connect". Mucosal Immunol 53 982 PMID: 23878024

Do you know of a great paper that uses Fexofenadine hydrochloride from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

GPCR Product Listing

GPCR Product Listing

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Histamine Receptors Scientific Review

Histamine Receptors Scientific Review

Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.