Fexaramine

Pricing Availability Delivery Time Qty
Cat.No. 2563 - Fexaramine | C32H36N2O3 | CAS No. 574013-66-4
Description: Potent, selective farnesoid X receptor (FXR) agonist
Chemical Name: 3-[3-[(Cyclohexylcarbonyl)-[[4'-(dimethylamino)-[1,1'-biphenyl]-4-yl]methyl]amino]phenyl]-2-propenoic acid methyl ester
Purity: ≥97% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Potent, selective farnesoid X receptor agonist (EC50 = 25 nM). Displays no activity at hRXRα, hPPARα, hPPARγ, hPPARδ, mPXR, hPXR, hLXRα, hTRβ, hRARβ, mCAR, mERRγ and hVDR receptors.

Compound Libraries

Fexaramine is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 496.64
Formula C32H36N2O3
Storage Desiccate at +4°C
Purity ≥97% (HPLC)
CAS Number 574013-66-4
PubChem ID 5326713
InChI Key VLQTUNDJHLEFEQ-KGENOOAVSA-N
Smiles O=C(C3CCCCC3)N(CC2=CC=C(C4=CC=C(N(C)C)C=C4)C=C2)C1=CC(/C=C/C(OC)=O)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 49.66 100

Preparing Stock Solutions

The following data is based on the product molecular weight 496.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.01 mL 10.07 mL 20.14 mL
5 mM 0.4 mL 2.01 mL 4.03 mL
10 mM 0.2 mL 1.01 mL 2.01 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the biological activity of the product.

Nicolaou et al (2003) Discovery and optimization of non-steroidal FXR agonists from natural product-like libraries. Org.Biomol.Chem. 1 908 PMID: 12929628

Downes et al (2003) A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. Mol.Cell 11 1079 PMID: 12718892

Pellicciari et al (2006) Back door modulation of the farnesoid X receptor: design, synthesis, and biological evaluation of a series of side chain modified chenodeoxycholic acid derivatives. J.Med.Chem. 49 4208 PMID: 16821780


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Keywords: Fexaramine, Fexaramine supplier, Potent, selective, farnesoid, X, receptor, FXR, agonists, Receptors, Liver, Farnesoid, LXR-like, 2563, Tocris Bioscience

1 Citation for Fexaramine

Citations are publications that use Tocris products. Selected citations for Fexaramine include:

Nagiec et al (2015) Modulators of hepatic lipoprotein metabolism identified in a search for small-molecule inducers of tribbles pseudokinase 1 expression. J Endocrinol 10 e0120295 PMID: 25811180


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Literature in this Area

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