Fexaramine

Pricing Availability Delivery Time Qty
Cat.No. 2563 - Fexaramine | C32H36N2O3 | CAS No. 574013-66-4
Description: Potent, selective farnesoid X receptor (FXR) agonist
Chemical Name: 3-[3-[(Cyclohexylcarbonyl)-[[4'-(dimethylamino)-[1,1'-biphenyl]-4-yl]methyl]amino]phenyl]-2-propenoic acid methyl ester
Purity: ≥97% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Potent, selective farnesoid X receptor agonist (EC50 = 25 nM). Displays no activity at hRXRα, hPPARα, hPPARγ, hPPARδ, mPXR, hPXR, hLXRα, hTRβ, hRARβ, mCAR, mERRγ and hVDR receptors.

Compound Libraries

Fexaramine is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 496.64
Formula C32H36N2O3
Storage Desiccate at +4°C
Purity ≥97% (HPLC)
CAS Number 574013-66-4
PubChem ID 5326713
InChI Key VLQTUNDJHLEFEQ-KGENOOAVSA-N
Smiles O=C(C3CCCCC3)N(CC2=CC=C(C4=CC=C(N(C)C)C=C4)C=C2)C1=CC(/C=C/C(OC)=O)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 49.66 100

Preparing Stock Solutions

The following data is based on the product molecular weight 496.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.01 mL 10.07 mL 20.14 mL
5 mM 0.4 mL 2.01 mL 4.03 mL
10 mM 0.2 mL 1.01 mL 2.01 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Nicolaou et al (2003) Discovery and optimization of non-steroidal FXR agonists from natural product-like libraries. Org.Biomol.Chem. 1 908 PMID: 12929628

Downes et al (2003) A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. Mol.Cell 11 1079 PMID: 12718892

Pellicciari et al (2006) Back door modulation of the farnesoid X receptor: design, synthesis, and biological evaluation of a series of side chain modified chenodeoxycholic acid derivatives. J.Med.Chem. 49 4208 PMID: 16821780


If you know of a relevant reference for Fexaramine, please let us know.

View Related Products by Target

View Related Products by Product Action

View all LXR-like Receptor Agonists

Keywords: Fexaramine, supplier, Potent, selective, farnesoid, X, receptor, FXR, agonists, Receptors, Liver, Farnesoid, LXR-like, LXR-like, Receptors, LXR-like, Receptors, Tocris Bioscience

1 Citation for Fexaramine

Citations are publications that use Tocris products. Selected citations for Fexaramine include:

Nagiec et al (2015) Modulators of hepatic lipoprotein metabolism identified in a search for small-molecule inducers of tribbles pseudokinase 1 expression. J Endocrinol 10 e0120295 PMID: 25811180


Do you know of a great paper that uses Fexaramine from Tocris? If so please let us know.

Fexaramine Reviews

Average Rating:

(Based on 0 Reviews)


1 Star
0%
2 Star
0%
3 Star
0%
4 Star
0%
5 Star
0%

Have you used Fexaramine?

Submit a review and receive a $25US/€18/£15/$25CAN Amazon gift card if you include an image -$10US/€7/£6/$10CAN Amazon gift card for reviews without an image. Limited to verified customers in USA, Canada and Europe.


Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Nuclear Receptors

Nuclear Receptors Product Listing

A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

  • Androgen Receptors
  • Estrogen Receptors
  • Retinoic Acid Receptors
  • Retinoid X Receptors
  • Vitamin D Receptors