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Biological Activity for Fexaramine
Fexaramine is a potent, selective farnesoid X receptor agonist (EC50 = 25 nM). Displays no activity at hRXRα, hPPARα, hPPARγ, hPPARδ, mPXR, hPXR, hLXRα, hTRβ, hRARβ, mCAR, mERRγ and hVDR receptors.
Compound Libraries for Fexaramine
Technical Data for Fexaramine
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Fexaramine
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Fexaramine
The following data is based on the product molecular weight 496.64. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.01 mL||10.07 mL||20.14 mL|
|5 mM||0.4 mL||2.01 mL||4.03 mL|
|10 mM||0.2 mL||1.01 mL||2.01 mL|
|50 mM||0.04 mL||0.2 mL||0.4 mL|
References for Fexaramine
References are publications that support the biological activity of the product.
Nicolaou et al (2003) Discovery and optimization of non-steroidal FXR agonists from natural product-like libraries. Org.Biomol.Chem. 1 908 PMID: 12929628
Downes et al (2003) A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. Mol.Cell 11 1079 PMID: 12718892
Pellicciari et al (2006) Back door modulation of the farnesoid X receptor: design, synthesis, and biological evaluation of a series of side chain modified chenodeoxycholic acid derivatives. J.Med.Chem. 49 4208 PMID: 16821780
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Keywords: Fexaramine, Fexaramine supplier, Potent, selective, farnesoid, X, receptor, FXR, agonists, Receptors, Liver, Farnesoid, LXR-like, 2563, Tocris Bioscience
1 Citation for Fexaramine
Citations are publications that use Tocris products. Selected citations for Fexaramine include:
Nagiec et al (2015) Modulators of hepatic lipoprotein metabolism identified in a search for small-molecule inducers of tribbles pseudokinase 1 expression. J Endocrinol 10 e0120295 PMID: 25811180
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Literature in this Area
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