CXCR4 antagonist (IC50 = 126 nM). Displays anti-HIV activity in assays using NL4-3 and IIIB strains (EC50 = 21 nM for both strains).
|Sequence||XGYRR (Modifications: Cyclic peptide, X = 2-Nal, Tyr-3 = D-Tyr]|
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 2 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 729.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.37 mL||6.85 mL||13.7 mL|
|5 mM||0.27 mL||1.37 mL||2.74 mL|
|10 mM||0.14 mL||0.69 mL||1.37 mL|
|50 mM||0.03 mL||0.14 mL||0.27 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Tamamura et al (2005) Stereoselective synthesis of [L-Arg-L/D-3-(2-naphthyl)alanine]-type (E)-alkene dipeptide isosteres and its application to the synthesis and biological evaluation of pseudopeptide analogues of the CXCR4 antagonist FC131 J.Med.Chem. 48 380 PMID: 15658852
If you know of a relevant reference for FC 131, please let us know.
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Keywords: FC131 cxcr4 antagonists chemokines receptors anti-HIV Chemokine CXC Receptors
Citations for FC 131
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