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CXCR4 antagonist (IC50 = 126 nM). Displays anti-HIV activity in assays using NL4-3 and IIIB strains (EC50 = 21 nM for both strains).
|Sequence||XGYRR (Modifications: Cyclic peptide, X = 2-Nal, Tyr-3 = D-Tyr]|
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 2 mg/ml in water|
References are publications that support the biological activity of the product.
Tamamura et al (2005) Stereoselective synthesis of [L-Arg-L/D-3-(2-naphthyl)alanine]-type (E)-alkene dipeptide isosteres and its application to the synthesis and biological evaluation of pseudopeptide analogues of the CXCR4 antagonist FC131 J.Med.Chem. 48 380 PMID: 15658852
Inokuchi et al (2011) Potent CXCR4 antagonists containing amidine type peptide bond isosteres. ACS Med.Chem.Lett. 2 477
If you know of a relevant reference for FC 131, please let us know.
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Keywords: FC 131, FC 131 supplier, FC131, cxcr4, antagonists, chemokines, receptors, anti-HIV, Antivirals, Chemokine, CXC, Receptors, 4320, Tocris Bioscience
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