FC 131

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Cat.No. 4320 - FC 131 | Cyclo[2-Nal-Gly-D-Tyr-Arg-Arg] | CAS No. 606968-52-9
Description: CXCR4 antagonist
Datasheet
Citations
Literature

Biological Activity

CXCR4 antagonist (IC50 = 126 nM). Displays anti-HIV activity in assays using NL4-3 and IIIB strains (EC50 = 21 nM for both strains).

Technical Data

M. Wt 729.84
Formula C36H47N11O6
Sequence XGYRR (Modifications: Cyclic peptide, X = 2-Nal, Tyr-3 = D-Tyr]
Storage Store at -20°C
CAS Number 606968-52-9
PubChem ID 5275848
InChI Key MBXBICVKLVYNKD-QUAHOIDUSA-N
Smiles NC(=N)NCCC[C@@H]1NC(=O)[C@@H](CC2=CC=C(O)C=C2)NC(=O)CNC(=O)[C@@H](CC2=CC3=CC=CC=C3C=C2)NC(=O)[C@H](CCCNC(N)=N)NC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 2 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 729.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.37 mL 6.85 mL 13.7 mL
5 mM 0.27 mL 1.37 mL 2.74 mL
10 mM 0.14 mL 0.69 mL 1.37 mL
50 mM 0.03 mL 0.14 mL 0.27 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Tamamura et al (2005) Stereoselective synthesis of [L-Arg-L/D-3-(2-naphthyl)alanine]-type (E)-alkene dipeptide isosteres and its application to the synthesis and biological evaluation of pseudopeptide analogues of the CXCR4 antagonist FC131 J.Med.Chem. 48 380 PMID: 15658852

Inokuchi et al (2011) Potent CXCR4 antagonists containing amidine type peptide bond isosteres. ACS Med.Chem.Lett. 2 477 PMID:


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Keywords: FC131 cxcr4 antagonists chemokines receptors anti-HIV Chemokine CXC Receptors

Citations for FC 131

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Literature in this Area

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