CXCR4 antagonist (IC50 = 126 nM). Displays anti-HIV activity in assays using NL4-3 and IIIB strains (EC50 = 21 nM for both strains).
|Sequence||XGYRR (Modifications: Cyclic peptide, X = 2-Nal, Tyr-3 = D-Tyr]|
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 2 mg/ml in water|
References are publications that support the biological activity of the product.
Tamamura et al (2005) Stereoselective synthesis of [L-Arg-L/D-3-(2-naphthyl)alanine]-type (E)-alkene dipeptide isosteres and its application to the synthesis and biological evaluation of pseudopeptide analogues of the CXCR4 antagonist FC131 J.Med.Chem. 48 380 PMID: 15658852
Inokuchi et al (2011) Potent CXCR4 antagonists containing amidine type peptide bond isosteres. ACS Med.Chem.Lett. 2 477
If you know of a relevant reference for FC 131, please let us know.
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Keywords: FC 131, FC 131 supplier, FC131, cxcr4, antagonists, chemokines, receptors, anti-HIV, Antivirals, Chemokine, CXC, Receptors, 4320, Tocris Bioscience
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Literature in this Area
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