Favipiravir

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Cat.No. 7225 - Favipiravir | C5H4FN3O2 | CAS No. 259793-96-9
Description: Viral RNA polymerase inhibitor
Alternative Names: T 705
Chemical Name: 6-Fluoro-3,4-dihydro-3-oxo-2-pyrazinecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

Viral RNA polymerase inhibitor; exhibits no effects on mammalian RNA polymerase. Prodrug that is phosphoribosylated by cellular enzymes to its active form, Favipiravir-ribofuranosyl-5'-triphosphate (RTP). Reduces infection rate of SARS-CoV-2 in Vero E6 cells in vitro (IC50 = 61.88 μM). Inhibits influenza virus RNA-dependent RNA polymerase (RdRP) activity (IC50 = 341 nM). Induces lethal mutagenesis in MDCK cells inoculated with seasonal influenza A (H1N1) viruses. Protects mice against Ebola virus.

Compound Libraries

Favipiravir is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 157.1
Formula C5H4FN3O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 259793-96-9
PubChem ID 492405
InChI Key ZCGNOVWYSGBHAU-UHFFFAOYSA-N
Smiles NC(C1=NC(F)=CNC1=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 15.71 100
ethanol 3.14 20

Preparing Stock Solutions

The following data is based on the product molecular weight 157.1. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.37 mL 31.83 mL 63.65 mL
5 mM 1.27 mL 6.37 mL 12.73 mL
10 mM 0.64 mL 3.18 mL 6.37 mL
50 mM 0.13 mL 0.64 mL 1.27 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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References

References are publications that support the biological activity of the product.

Wang et al (2020) Remdesivir and Chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 30 269 PMID: 32020029

Furuta et al (2002) In vitro and in vivo activities of anti-influenza virus compound T-705. Antimicrob.Agents Chemother. 46 977 PMID: 11897578


If you know of a relevant reference for Favipiravir, please let us know.

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Citations for Favipiravir

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Literature in this Area

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