Fatostatin A

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Cat.No. 4444 - Fatostatin A | C18H18N2S.HBr | CAS No. 298197-04-3
Description: Cell permeable inhibitor of SREBP activation
Chemical Name: 4-[4-(4-Methylphenyl)-2-thiazolyl]-2-propylpyridine hydrobromide
Purity: ≥97% (HPLC)
Datasheet
Citations
Reviews
Literature
Pathways

Biological Activity

Inhibitor of sterol regulatory element binding protein (SREBP); impairs the activation of SREBP-1 and SREBP-2. Exhibits antiproliferative effects in DU 145 cells independently of IGF-1 signaling (IC50 = 0.1 μM); reverses hyperglycemia in diabetic (ob/ob) mice. Cell permeable.

Technical Data

M. Wt 375.33
Formula C18H18N2S.HBr
Storage Store at +4°C
Purity ≥97% (HPLC)
CAS Number 298197-04-3
PubChem ID 2850562
InChI Key RJCFNQZVFUMORB-UHFFFAOYSA-N
Smiles CCCC1=CC(C2=NC(C3=CC=C(C)C=C3)=CS2)=CC=N1.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.51 20

Preparing Stock Solutions

The following data is based on the product molecular weight 375.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 13.32 mL 66.61 mL 133.22 mL
1 mM 2.66 mL 13.32 mL 26.64 mL
2 mM 1.33 mL 6.66 mL 13.32 mL
10 mM 0.27 mL 1.33 mL 2.66 mL

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References

References are publications that support the biological activity of the product.

Kamisuki et al (2009) A small molecule that blocks fat synthesis by inhibiting the activation of SREBP. Chem.Biol. 16 882 PMID: 19716478

Choi et al (2003) Identification of bioactive molecules by adipogenesis profiling of organic compounds. J.Biol.Chem. 278 7320 PMID: 12496288


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Citations for Fatostatin A

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Literature in this Area

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Pathways for Fatostatin A

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