Famotidine

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Cat.No. 7290 - Famotidine | C8H15N7O2S3 | CAS No. 76824-35-6
Description: Potent and high affinity H2 biased inverse agonist
Chemical Name: 3-[[[2-[(Aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]-N-(aminosulfonyl)propanimidamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity

Potent and high affinity histamine H2 receptor biased inverse agonist (Kd = 14 nM, IC50 = 33 nM). Reduces basal receptor activity by 75%. Inhibits Gs-mediated pathways but acts as a partial agonist of β-arrestin recruitment (EC50 = 105 nM). Inhibits gastric acid secretion and histamine-induced mast cell activation. Also inhibits HIV replication in vitro.

Technical Data

M. Wt 337.44
Formula C8H15N7O2S3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 76824-35-6
PubChem ID 3325
InChI Key XUFQPHANEAPEMJ-UHFFFAOYSA-N
Smiles NC(=N)NC1=NC(CSCCC(=N)N[S](N)(=O)=O)=CS1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.74 100

Preparing Stock Solutions

The following data is based on the product molecular weight 337.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.96 mL 14.82 mL 29.63 mL
5 mM 0.59 mL 2.96 mL 5.93 mL
10 mM 0.3 mL 1.48 mL 2.96 mL
50 mM 0.06 mL 0.3 mL 0.59 mL

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References

References are publications that support the biological activity of the product.

Takagi et al (1982) Effect of a new potent H2-blocker, 3-[[[2-[(diaminomethylene)amino]-4-thiazolyl]methyl]-thio]-N2-sulfamoylpropionamidine (YM-11170) on gastric secretion induced by histamine and food in conscious dogs. Arch.Int.Pharmacodyn.Ther. 256 49 PMID: 6124219

Pendleton et al (1985) Effects of H2-receptor antagonists upon physiological acid secretory states in animals. J.Pharmacol.Exp.Ther. 233 64 PMID: 2858583

Bourinbaiar & Fruhstorfer (1996) The effect of histamine type 2 receptor antagonists on human immunodeficiency virus (HIV) replication: identification of a new class of antiviral agents. Life Sci. 59 365 PMID: 8950301

Malone et al (2020) COVID-19: Famotidine, histamine, mast cells, and mechanisms. Res.Sq. - Paper not yet peer reviewed PMID: 32702719


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Keywords: Famotidine, Famotidine supplier, YM, 11170, MK, 208, histamine, h2, receptor, inverse, agonists, antagonists, biased, signaling, antiviral, COVID-19, mast, cell, activation, Histamine, H2, Receptors, Antivirals, HIV, 7290, Tocris Bioscience

Citations for Famotidine

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