Exemestane
Biological Activity
Irreversible steroidal aromatase inhibitor (IC50 = 20 nM). Destabilizes aromatase and lowers estrogen levels; orally active.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Compound Libraries
Exemestane is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 296.4 |
| Formula | C20H24O2 |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 107868-30-4 |
| PubChem ID | 60198 |
| InChI Key | BFYIZQONLCFLEV-DAELLWKTSA-N |
| Smiles | C[C@@]12C(C(C[C@]3([H])[C@@]([H])2CC[C@@]4(C)[C@]([H])3CCC4=O)=C)=CC(C=C1)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.64 | 100 | |
| ethanol | 22.23 | 75 |
Preparing Stock Solutions
The following data is based on the product molecular weight 296.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.37 mL | 16.87 mL | 33.74 mL |
| 5 mM | 0.67 mL | 3.37 mL | 6.75 mL |
| 10 mM | 0.34 mL | 1.69 mL | 3.37 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.67 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Goss et al (2004) The steroidal aromatase inhibitor exemestane prevents bone loss in ovariectomized rats. Bone 34 384 PMID: 15003786
Wang and Chen (2006) Aromatase destabilizer: novel action of exemestane, a Food and Drug Administration-approved aromatase inhibitor. Cancer Res. 66 10281 PMID: 17079446
Miller et al (2008) Aromatase inhibitors: are there differences between steroidal and nonsteroidal aromatase inhibitors and do they matter? Oncologist 13 829 PMID: 18695261
di Salle et al (1992) Exemestane (FCE 24304), a new steroidal aromatase inhibitor. J.Steroid Biochem.Molec.Bio. 43 137 PMID:
If you know of a relevant reference for Exemestane, please let us know.
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Keywords: Pfizer aromatase inhibitors inhibits estrogen synthesis CYP19 Cytochrome P450 FCE24304 FCE 24304 EXE Cytochrome P450
Citations for Exemestane
Citations are publications that use Tocris products.
Currently there are no citations for Exemestane. Do you know of a great paper that uses Exemestane from Tocris? If so please let us know.
Literature in this Area
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