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Submit ReviewExemestane
Description: Steroidal aromatase (CYP19) inhibitor
Alternative Names: FCE 24304, EXE
Chemical Name: 6-Methyleneandrosta-1,4-diene-3,17-dione
Purity: ≥99% (HPLC)
Biological Activity for Exemestane
Exemestane is an irreversible steroidal aromatase inhibitor (IC50 = 20 nM). Destabilizes aromatase and lowers estrogen levels; orally active.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Compound Libraries for Exemestane
Exemestane is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
Technical Data for Exemestane
| M. Wt | 296.4 |
| Formula | C20H24O2 |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 107868-30-4 |
| PubChem ID | 60198 |
| InChI Key | BFYIZQONLCFLEV-DAELLWKTSA-N |
| Smiles | C[C@@]12C(C(C[C@]3([H])[C@@]([H])2CC[C@@]4(C)[C@]([H])3CCC4=O)=C)=CC(C=C1)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Exemestane
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.64 | 100 | |
| ethanol | 22.23 | 75 |
Preparing Stock Solutions for Exemestane
The following data is based on the product molecular weight 296.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.37 mL | 16.87 mL | 33.74 mL |
| 5 mM | 0.67 mL | 3.37 mL | 6.75 mL |
| 10 mM | 0.34 mL | 1.69 mL | 3.37 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.67 mL |
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Product Datasheets for Exemestane
References for Exemestane
References are publications that support the biological activity of the product.
Goss et al (2004) The steroidal aromatase inhibitor exeme. prevents bone loss in ovariectomized rats. Bone 34 384 PMID: 15003786
Wang and Chen (2006) Aromatase destabilizer: novel action of exemestane, a Food and Drug Administration-approved aromatase inhibitor. Cancer Res. 66 10281 PMID: 17079446
Miller et al (2008) Aromatase inhibitors: are there differences between steroidal and nonsteroidal aromatase inhibitors and do they matter? Oncologist 13 829 PMID: 18695261
di Salle et al (1992) Exemestane (FCE 24304), a new steroidal aromatase inhibitor. J.Steroid Biochem.Molec.Bio. 43 137
If you know of a relevant reference for Exemestane, please let us know.
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Keywords: Exemestane, Exemestane supplier, Pfizer, aromatase, inhibitors, inhibits, estrogen, synthesis, CYP19, Cytochrome, P450, FCE24304, FCE, 24304, EXE, 3759, Tocris Bioscience
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