Home / Pharmacology / Enzymes / Cytochrome P450 / Cytochrome P450 Inhibitors / Exemestane

Exemestane

Cat. No. 3759 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Cat.No. 3759 - Exemestane | C20H24O2 | CAS No. 107868-30-4
Description: Steroidal aromatase (CYP19) inhibitor
Alternative Names: FCE 24304, EXE
Chemical Name: 6-Methyleneandrosta-1,4-diene-3,17-dione
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Irreversible steroidal aromatase inhibitor (IC50 = 20 nM). Destabilizes aromatase and lowers estrogen levels; orally active.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries

Exemestane is also offered as part of the Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 296.4
Formula C20H24O2
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 107868-30-4
PubChem ID 60198
InChI Key BFYIZQONLCFLEV-DAELLWKTSA-N
Smiles C[C@@]12C(C(C[C@]3([H])[C@@]([H])2CC[C@@]4(C)[C@]([H])3CCC4=O)=C)=CC(C=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.64 100
ethanol 22.23 75

Preparing Stock Solutions

The following data is based on the product molecular weight 296.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.37 mL 16.87 mL 33.74 mL
5 mM 0.67 mL 3.37 mL 6.75 mL
10 mM 0.34 mL 1.69 mL 3.37 mL
50 mM 0.07 mL 0.34 mL 0.67 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Goss et al (2004) The steroidal aromatase inhibitor exeme. prevents bone loss in ovariectomized rats. Bone 34 384 PMID: 15003786

Wang and Chen (2006) Aromatase destabilizer: novel action of exemestane, a Food and Drug Administration-approved aromatase inhibitor. Cancer Res. 66 10281 PMID: 17079446

Miller et al (2008) Aromatase inhibitors: are there differences between steroidal and nonsteroidal aromatase inhibitors and do they matter? Oncologist 13 829 PMID: 18695261

di Salle et al (1992) Exemestane (FCE 24304), a new steroidal aromatase inhibitor. J.Steroid Biochem.Molec.Bio. 43 137

If you know of a relevant reference for Exemestane, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Cytochrome P450 Inhibitors

Keywords: Exemestane, Exemestane supplier, Pfizer, aromatase, inhibitors, inhibits, estrogen, synthesis, CYP19, Cytochrome, P450, FCE24304, FCE, 24304, EXE, 3759, Tocris Bioscience

Citations for Exemestane

Citations are publications that use Tocris products.

Currently there are no citations for Exemestane. Do you know of a great paper that uses Exemestane from Tocris? Please let us know.

Reviews for Exemestane

There are currently no reviews for this product. Be the first to review Exemestane and earn rewards!

Have you used Exemestane?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

New Product Guide

New Product Guide [Spring/Summer 2019]

Our new product guide highlights over 215 new products added to the Tocris Bioscience range during the first half of 2019.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Chemogenetics
  • Epigenetics
  • Fluorescent Imaging
  • PROTACs
  • Signal Transduction
  • Stem Cells