Exemestane

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Cat.No. 3759 - Exemestane | C20H24O2 | CAS No. 107868-30-4
Description: Steroidal aromatase (CYP19) inhibitor
Alternative Names: FCE 24304, EXE
Chemical Name: 6-Methyleneandrosta-1,4-diene-3,17-dione
Purity: ≥99% (HPLC)
Datasheet
Citations
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Biological Activity for Exemestane

Exemestane is an irreversible steroidal aromatase inhibitor (IC50 = 20 nM). Destabilizes aromatase and lowers estrogen levels; orally active.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for Exemestane

Exemestane is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Exemestane

M. Wt 296.4
Formula C20H24O2
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 107868-30-4
PubChem ID 60198
InChI Key BFYIZQONLCFLEV-DAELLWKTSA-N
Smiles C[C@@]12C(C(C[C@]3([H])[C@@]([H])2CC[C@@]4(C)[C@]([H])3CCC4=O)=C)=CC(C=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Exemestane

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.64 100
ethanol 22.23 75

Preparing Stock Solutions for Exemestane

The following data is based on the product molecular weight 296.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.37 mL 16.87 mL 33.74 mL
5 mM 0.67 mL 3.37 mL 6.75 mL
10 mM 0.34 mL 1.69 mL 3.37 mL
50 mM 0.07 mL 0.34 mL 0.67 mL

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References for Exemestane

References are publications that support the biological activity of the product.

Goss et al (2004) The steroidal aromatase inhibitor exeme. prevents bone loss in ovariectomized rats. Bone 34 384 PMID: 15003786

Wang and Chen (2006) Aromatase destabilizer: novel action of exemestane, a Food and Drug Administration-approved aromatase inhibitor. Cancer Res. 66 10281 PMID: 17079446

Miller et al (2008) Aromatase inhibitors: are there differences between steroidal and nonsteroidal aromatase inhibitors and do they matter? Oncologist 13 829 PMID: 18695261

di Salle et al (1992) Exemestane (FCE 24304), a new steroidal aromatase inhibitor. J.Steroid Biochem.Molec.Bio. 43 137


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Keywords: Exemestane, Exemestane supplier, Pfizer, aromatase, inhibitors, inhibits, estrogen, synthesis, CYP19, Cytochrome, P450, FCE24304, FCE, 24304, EXE, 3759, Tocris Bioscience

Citations for Exemestane

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