Exemestane

Pricing Availability Delivery Time Qty
Cat.No. 3759 - Exemestane | C20H24O2 | CAS No. 107868-30-4
Description: Steroidal aromatase (CYP19) inhibitor
Alternative Names: FCE 24304, EXE
Chemical Name: 6-Methyleneandrosta-1,4-diene-3,17-dione
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Irreversible steroidal aromatase inhibitor (IC50 = 20 nM). Destabilizes aromatase and lowers estrogen levels; orally active.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries

Exemestane is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 296.4
Formula C20H24O2
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 107868-30-4
PubChem ID 60198
InChI Key BFYIZQONLCFLEV-DAELLWKTSA-N
Smiles C[C@@]12C(C(C[C@]3([H])[C@@]([H])2CC[C@@]4(C)[C@]([H])3CCC4=O)=C)=CC(C=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.64 100
ethanol 22.23 75

Preparing Stock Solutions

The following data is based on the product molecular weight 296.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.37 mL 16.87 mL 33.74 mL
5 mM 0.67 mL 3.37 mL 6.75 mL
10 mM 0.34 mL 1.69 mL 3.37 mL
50 mM 0.07 mL 0.34 mL 0.67 mL

Molarity Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Goss et al (2004) The steroidal aromatase inhibitor exemestane prevents bone loss in ovariectomized rats. Bone 34 384 PMID: 15003786

Wang and Chen (2006) Aromatase destabilizer: novel action of exemestane, a Food and Drug Administration-approved aromatase inhibitor. Cancer Res. 66 10281 PMID: 17079446

Miller et al (2008) Aromatase inhibitors: are there differences between steroidal and nonsteroidal aromatase inhibitors and do they matter? Oncologist 13 829 PMID: 18695261

di Salle et al (1992) Exemestane (FCE 24304), a new steroidal aromatase inhibitor. J.Steroid Biochem.Molec.Bio. 43 137 PMID:


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View all Cytochrome P450 Inhibitors

Keywords: Pfizer aromatase inhibitors inhibits estrogen synthesis CYP19 Cytochrome P450 FCE24304 FCE 24304 EXE Cytochrome P450

Citations for Exemestane

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New Product Guide (Spring/Summer 2017)

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Pathways for Exemestane

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