Discontinued Product

Etodolac (Cat. No. 3871) has been withdrawn from sale for commercial reasons.
Description: Selective cyclooxygenase-2 (COX-2) inhibitor; NSAID
Chemical Name: (RS)-2-(1,8-Diethyl-4,9-dihydro-3H-pyrano[3,4-b]indol-1-yl)acetic acid
Literature (2)

Biological Activity for Etodolac

Non-steroidal anti-inflammatory drug (NSAID) that selectively inhibits cyclooxygenase-2 (COX-2) (IC50 values are 53 and >100 μM for COX-2 and COX-1 respectively). Displays anti-inflammatory effects in both adjuvant arthritic and normal rats.

Technical Data for Etodolac

M. Wt 287.35
Formula C17H21NO3
Storage Store at +4°C
CAS Number 41340-25-4
PubChem ID 3308
Smiles CCC1(CC(O)=O)OCCC3=C1NC2=C(CC)C=CC=C23

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Etodolac

References are publications that support the biological activity of the product.

Kato et al (2001) Cyclooxygenase-1 and cyclooxygenase-2 selectivity of non-steroidal anti-inflammatory drugs: investigation using human peripheral monocytes. J.Pharm.Pharmacol. 53 1679 PMID: 11804398

Tachibana et al (2003) Anti-inflammatory effect and low ulcerogenic activity of etodolac, a cyclooxygenase-2 selective non-steroidal anti-inflammatory drug, on adjuvant-induced arthritis in rats. Pharmacology 68 96 PMID: 12711837

Shi et al (2004) Pharmacokinetic difference between S-(+)- and R-(-)-etodolac in rats. Acta Pharmacol.Sinica 25 996

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Keywords: Etodolac, Etodolac supplier, selective, cyclooxygenase-2, COX-2, inhibitors, inhibits, oxygenases, oxidases, nonsteroidal, anti-inflammatory, drug, NSAID, Cyclooxygenase, 3871, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Etodolac, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to

Citations for Etodolac

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Currently there are no citations for Etodolac.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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