ERGi-USU

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Cat.No. 6632 - ERGi-USU | C13H9N3OS | CAS No. 1147-56-4
Description: Rio2 kinase (RIOK2) inhibitor; inhibits ERG protein
Chemical Name: 1-[2-(2-Thiazolyl)diazenyl]-2-naphthalenol
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

High affinity Rio Kinase 2 (RIOK2) inhibitor (Kd = 200 nM). Exhibits >6-fold selectivity for RIOK2 over a panel of 456 kinases. Inhibits ERG protein and potently inhibits growth of ERG-positive VCaP prostate cancer cells in vitro (IC50 = 169 nM) but not ERG-negative cell lines. Also inhibits growth of VCaP xenografts in mice.

Technical Data

M. Wt 255.3
Formula C13H9N3OS
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1147-56-4
PubChem ID 6308684
InChI Key GCBAKGGJQPMJLL-QINSGFPZSA-N
Smiles OC1=C(C2=CC=CC=C2C=C1)/N=N/C3=NC=CS3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.53 100

Preparing Stock Solutions

The following data is based on the product molecular weight 255.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.92 mL 19.58 mL 39.17 mL
5 mM 0.78 mL 3.92 mL 7.83 mL
10 mM 0.39 mL 1.96 mL 3.92 mL
50 mM 0.08 mL 0.39 mL 0.78 mL

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References

References are publications that support the biological activity of the product.

Mohamed et al (2018) Identification of a small molecule that selectively inhibits ERG-positive cancer cell growth. Cancer Res. 78 3659 PMID: 29712692


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Keywords: ERGi-USU, ERGi-USU supplier, Rio2, kinase, RIOK2, atypical, protein, aPK, ribosome, biogenesis, inhibitors, inhibits, high, affinity, ERG, prostate, cancer, Other, Kinases, 6632, Tocris Bioscience

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