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Submit ReviewERGi-USU
Description: Rio2 kinase (RIOK2) inhibitor; inhibits ERG protein
Chemical Name: 1-[2-(2-Thiazolyl)diazenyl]-2-naphthalenol
Purity: ≥99% (HPLC)
Biological Activity for ERGi-USU
ERGi-USU is a high affinity Rio Kinase 2 (RIOK2) inhibitor (Kd = 200 nM). Exhibits >6-fold selectivity for RIOK2 over a panel of 456 kinases. Inhibits ERG protein and potently inhibits growth of ERG-positive VCaP prostate cancer cells in vitro (IC50 = 169 nM) but not ERG-negative cell lines. Also inhibits growth of VCaP xenografts in mice.
Technical Data for ERGi-USU
| M. Wt | 255.3 |
| Formula | C13H9N3OS |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 1147-56-4 |
| PubChem ID | 6308684 |
| InChI Key | GCBAKGGJQPMJLL-QINSGFPZSA-N |
| Smiles | OC1=C(C2=CC=CC=C2C=C1)/N=N/C3=NC=CS3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for ERGi-USU
References for ERGi-USU
References are publications that support the biological activity of the product.
Mohamed et al (2018) Identification of a small molecule that selectively inhibits ERG-positive cancer cell growth. Cancer Res. 78 3659 PMID: 29712692
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Keywords: ERGi-USU, ERGi-USU supplier, Rio2, kinase, RIOK2, atypical, protein, aPK, ribosome, biogenesis, inhibitors, inhibits, high, affinity, ERG, prostate, cancer, Other, Kinases, 6632, Tocris Bioscience
1 Citation for ERGi-USU
Citations are publications that use Tocris products. Selected citations for ERGi-USU include:
Marc et al (2021) Extracellular signal-regulated kinase mediates chromatin rewiring and lineage transformation in lung cancer. Elife 10 PMID: 34121659
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