Eprosartan mesylate

Discontinued Product

Unfortunately Eprosartan mesylate (Cat. No. 4696) has been withdrawn from sale for commercial reasons.
Cat.No. 4696 - Eprosartan mesylate | C23H24N2O4S.CH3SO3H | CAS No. 144143-96-4
Description: Potent and selective AT1 receptor antagonist
Alternative Names: SK&F 108566
Chemical Name: (αE)-α-[[2-Butyl-1-[(4-carboxyphenyl)methyl]-1H-imidazol-5-yl]methylene]-2-thiophenepropanoic acid methanesulfonate
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent angiotensin II receptor 1 (AT1) antagonist (IC50 values are 1.5, 1.7, 3.9 and 9.2 nM at rat mesenteric artery, human liver membrane, human adrenal cortical membrne and rat adrenal cortical membrane respectively). Displays no effect on vasopressin or CGRP binding, or angiotensin-converting enzyme (ACE) activity. Inhibits the angiotensin II-induced pressor response in normotensive rats.

Technical Data

M. Wt 520.62
Formula C23H24N2O4S.CH3SO3H
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 144143-96-4
PubChem ID 5282474
InChI Key DJSLTDBPKHORNY-XMMWENQYSA-N
Smiles CCCCC1=NC=C(/C=C(C(O)=O)\CC3=CC=CS3)N1CC2=CC=C(C(O)=O)C=C2.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 520.62. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.92 mL 9.6 mL 19.21 mL
5 mM 0.38 mL 1.92 mL 3.84 mL
10 mM 0.19 mL 0.96 mL 1.92 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Oh et al (2011) Angiotensin II inhibits insulin binding to endothelial cells. Diabetes Metab.J. 35 243 PMID: 21785744

Edwards et al (1992) Pharmacological characterization of the nonpeptide angiotensin II receptor antagonist, SK&F 108566. J.Pharmacol.Exp.Ther. 260 175 PMID: 1309870

View Related Products by Target

View Related Products by Product Action

View all Angiotensin AT1 Receptor Antagonists

Keywords: Eprosartan mesylate, supplier, SK&F, 108566, SK&F108566, angiotensin, II, AT1, receptors, antagonists, inhibits, potent, selective, competitive, SK&F, 108566, Angiotensin, AT1, Receptors, Angiotensin, AT1, Receptors, Tocris Bioscience

Citations for Eprosartan mesylate

Citations are publications that use Tocris products.

Currently there are no citations for Eprosartan mesylate.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Peptide Hormone Receptors

Peptide Hormone Receptors Product Listing

A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:

  • Anterior Pituitary Regulation
  • Blood Pressure Regulation
  • Feeding and Appetite Regulation
  • Glucose Regulation
  • Peptide Hormone Processing
Cardiovascular

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Pathways for Eprosartan mesylate

Protocols

TODO: Add Protocols