Discontinued ProductUnfortunately Eprosartan mesylate (Cat. No. 4696) has been withdrawn from sale for commercial reasons.
Potent angiotensin II receptor 1 (AT1) antagonist (IC50 values are 1.5, 1.7, 3.9 and 9.2 nM at rat mesenteric artery, human liver membrane, human adrenal cortical membrne and rat adrenal cortical membrane respectively). Displays no effect on vasopressin or CGRP binding, or angiotensin-converting enzyme (ACE) activity. Inhibits the angiotensin II-induced pressor response in normotensive rats.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 520.62. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.92 mL||9.6 mL||19.21 mL|
|5 mM||0.38 mL||1.92 mL||3.84 mL|
|10 mM||0.19 mL||0.96 mL||1.92 mL|
|50 mM||0.04 mL||0.19 mL||0.38 mL|
References are publications that support the products' biological activity.
Oh et al (2011) Angiotensin II inhibits insulin binding to endothelial cells. Diabetes Metab.J. 35 243 PMID: 21785744
Edwards et al (1992) Pharmacological characterization of the nonpeptide angiotensin II receptor antagonist, SK&F 108566. J.Pharmacol.Exp.Ther. 260 175 PMID: 1309870
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Keywords: Eprosartan mesylate, supplier, SK&F, 108566, SK&F108566, angiotensin, II, AT1, receptors, antagonists, inhibits, potent, selective, competitive, SK&F, 108566, Angiotensin, AT1, Receptors, Angiotensin, AT1, Receptors, Tocris Bioscience
Citations for Eprosartan mesylate
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