Eprosartan mesylate

Discontinued Product

Eprosartan mesylate (Cat. No. 4696) has been withdrawn from sale for commercial reasons.
Description: Potent and selective AT1 receptor antagonist
Alternative Names: SK&F 108566
Chemical Name: (αE)-α-[[2-Butyl-1-[(4-carboxyphenyl)methyl]-1H-imidazol-5-yl]methylene]-2-thiophenepropanoic acid methanesulfonate
Purity: ≥99% (HPLC)

Biological Activity for Eprosartan mesylate

Potent angiotensin II receptor 1 (AT1) antagonist (IC50 values are 1.5, 1.7, 3.9 and 9.2 nM at rat mesenteric artery, human liver membrane, human adrenal cortical membrne and rat adrenal cortical membrane respectively). Displays no effect on vasopressin or CGRP binding, or angiotensin-converting enzyme (ACE) activity. Inhibits the angiotensin II-induced pressor response in normotensive rats.

Technical Data for Eprosartan mesylate

M. Wt 520.62
Formula C23H24N2O4S.CH3SO3H
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 144143-96-4
PubChem ID 5282474
Smiles CCCCC1=NC=C(/C=C(C(O)=O)\CC3=CC=CS3)N1CC2=CC=C(C(O)=O)C=C2.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Eprosartan mesylate

References for Eprosartan mesylate

References are publications that support the biological activity of the product.

Oh et al (2011) Angiotensin II inhibits Ins binding to endothelial cells. Diabetes Metab.J. 35 243 PMID: 21785744

Edwards et al (1992) Pharmacological characterization of the nonpeptide angiotensin II receptor antagonist, SK&F 108566. J.Pharmacol.Exp.Ther. 260 175 PMID: 1309870

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