EPPTB

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Description: Trace amine 1 (TA1) receptor antagonist; also displays inverse agonism
Chemical Name: N-(3-Ethoxyphenyl)-4-(1-pyrrolidinyl)-3-(trifluoromethyl)benzamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews (1)
Literature (2)

Biological Activity for EPPTB

EPPTB is a trace amine 1 (TA1) receptor antagonist/inverse agonist; exhibits a higher potency at the mouse TA1 receptor than the rat and human TA1 receptors (IC50 values are 27.5, 4539 and 7487 nM, respectively). Blocks the TA1 receptor-mediated activation of an inwardly rectifying K+ current, which increases the firing frequency of dopamine (DA) neurons in the ventral tegmental area. Increases DA potency at the D2 receptor. Also displays inverse agonism, reducing basal cAMP levels in vitro (IC50 = 19 nM).

Compound Libraries for EPPTB

EPPTB is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for EPPTB

M. Wt 378.39
Formula C20H21F3N2O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1110781-88-8
PubChem ID 25175634
InChI Key KLFVWQCQUXXLOU-UHFFFAOYSA-N
Smiles O=C(NC3=CC(OCC)=CC=C3)C1=CC(C(F)(F)F)=C(N2CCCC2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for EPPTB

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.84 100
ethanol 37.84 100

Preparing Stock Solutions for EPPTB

The following data is based on the product molecular weight 378.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.64 mL 13.21 mL 26.43 mL
5 mM 0.53 mL 2.64 mL 5.29 mL
10 mM 0.26 mL 1.32 mL 2.64 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

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References for EPPTB

References are publications that support the biological activity of the product.

Bradaia et al (2009) The selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in DArgic neurons of the mesolimbic system. Proc.Natl.Acad.Sci.U.S.A. 106 20081 PMID: 19892733


If you know of a relevant reference for EPPTB, please let us know.

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Keywords: EPPTB, EPPTB supplier, Parkinson's, disease, trace, amine-associated, receptors, 1, TAAR1, antagonists, dopamine, neurons, neurones, TA1, Trace, Amine, Receptor, 4518, Tocris Bioscience

Citations for EPPTB

Citations are publications that use Tocris products.

Currently there are no citations for EPPTB. Do you know of a great paper that uses EPPTB from Tocris? Please let us know.

Reviews for EPPTB

Average Rating: 2 (Based on 1 Review.)

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Only Specific to mouse TAAR1.
By Alex Voisey on 12/31/2019
Assay Type: In Vitro
Species: Rat

1-5 uM in organ bath for rat isolated aortic rings

only use for mouse tissues, all publications using this product are in mice

review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Dopamine Receptors Scientific Review

Dopamine Receptors Scientific Review

Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.