Enzastaurin

Discontinued Product

Enzastaurin (Cat. No. 5994) has been withdrawn from sale for commercial reasons.
Description: Potent PKCβ inhibitor
Alternative Names: LY317615
Chemical Name: 3-(1-Methyl-1H-indol-3-yl)-4-[1-[1-(2-pyridinylmethyl)-4-piperidinyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews

Biological Activity for Enzastaurin

Enzastaurin is a potent PKCβ inhibitor (IC50 values are 6, 39, 83 and 110 nM for PKCβ, PKCα, PKCγ and PKCε, respectively). Suppresses proliferation and induces apoptosis in HCT116 colon carcinoma and U87MG glioblastoma cells in vitro. Reduces tumor growth and exhibits antiangiogenic activity in HT-29 colon carcinoma xenografts in mice. Also suppresses growth of HCT116 and U87MG xenografts in mice. Orally active.

Technical Data for Enzastaurin

M. Wt 515.6
Formula C32H29N5O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 170364-57-5
PubChem ID 176167
InChI Key AXRCEOKUDYDWLF-UHFFFAOYSA-N
Smiles CN1C=C(C2=C(C3=CN(C4=C3C=CC=C4)C5CCN(CC5)CC6=CC=CC=N6)C(NC2=O)=O)C7=C1C=CC=C7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Enzastaurin

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