Entecavir

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Cat.No. 6234 - Entecavir | C12H15N5O3 | CAS No. 142217-69-4
Description: Potent and selective hepatitis B virus inhibitor
Alternative Names: BMS 200475, SQ 34676
Chemical Name: 2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent and selective hepatitis B virus reverse transcriptase inhibitor (EC50 = 3 nM); guanine analog. Inhibits hepatitis B virus replication in HepG2.2.15 cells. Displays selectively over HCMV, HSV-1, VZV, HIV and influenza (EC50 values are 15, 32, 30-60, >10 and >80 μM respectively). Orally bioavailable.

Technical Data

M. Wt 277.28
Formula C12H15N5O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 142217-69-4
PubChem ID 153941
InChI Key QDGZDCVAUDNJFG-FXQIFTODSA-N
Smiles O=C1C2=C(N([C@H]3C[C@H](O)[C@@H](CO)C3=C)C=N2)NC(N)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 27.73 100

Preparing Stock Solutions

The following data is based on the product molecular weight 277.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.61 mL 18.03 mL 36.06 mL
5 mM 0.72 mL 3.61 mL 7.21 mL
10 mM 0.36 mL 1.8 mL 3.61 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Innaimo et al (1997) Identification of BMS-200475 as a potent and selective inhibitor of hepatitis B virus. Antimicrob. Agents Chemother. 41 1444 PMID: 9210663

Bisacchi et al (1997) BMS-200475, a novel carbocyclic 2'-deoxyguanosine analog with potent and selective anti-hepatitis B virus activity in vitro Bioorganic & Medicinal Chemistry Letters 7 127 PMID:


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