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Biological Activity for EMI 48
EMI 48 is an inhibitor of mutant EGFR; it inhibits L858R/T970M/C797S mutants and ex19del/T790M/C797S triple mutants (inhibitory effects at 5 μM) but has no effect on wild-type EGFR. EMI 48 induces EGFR degradation (<5 μM), and inhibits activation of ERK, S6 and AKT.
Technical Data for EMI 48
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for EMI 48
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||6.97||20 with gentle warming|
Preparing Stock Solutions for EMI 48
The following data is based on the product molecular weight 348.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||14.35 mL||71.76 mL||143.51 mL|
|1 mM||2.87 mL||14.35 mL||28.7 mL|
|2 mM||1.44 mL||7.18 mL||14.35 mL|
|10 mM||0.29 mL||1.44 mL||2.87 mL|
References for EMI 48
References are publications that support the biological activity of the product.
Saraon et al (2020) A drug discovery platform to identify compounds that inhibit EGFR triple mutants. Nat.Chem.Biol. 16 577 PMID: 32094923
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Keywords: EMI 48, EMI 48 supplier, EMI48, EGFR, inhibitors, inhibits, degradation, mutant, endothelial, growth, factors, receptors, L858R, T970M, C797S, ex19del, 7424, Tocris Bioscience
Citations for EMI 48
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Literature in this Area
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