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EMI 48 is an inhibitor of mutant EGFR; it inhibits L858R/T970M/C797S mutants and ex19del/T790M/C797S triple mutants (inhibitory effects at 5 μM) but has no effect on wild-type EGFR. EMI 48 induces EGFR degradation (<5 μM), and inhibits activation of ERK, S6 and AKT.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||6.97||20 with gentle warming|
The following data is based on the product molecular weight 348.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||14.35 mL||71.76 mL||143.51 mL|
|1 mM||2.87 mL||14.35 mL||28.7 mL|
|2 mM||1.44 mL||7.18 mL||14.35 mL|
|10 mM||0.29 mL||1.44 mL||2.87 mL|
References are publications that support the biological activity of the product.
Saraon et al (2020) A drug discovery platform to identify compounds that inhibit EGFR triple mutants. Nat.Chem.Biol. 16 577 PMID: 32094923
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Keywords: EMI 48, EMI 48 supplier, EMI48, EGFR, inhibitors, inhibits, degradation, mutant, endothelial, growth, factors, receptors, L858R, T970M, C797S, ex19del, 7424, Tocris Bioscience
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.