EMI 48

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Description: Inhibitor of EGFR mutants
Chemical Name: 7-(Diethylamino)-3-(5-methyl-2-benzoxazolyl)-2H-1-benzopyran-2-one
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for EMI 48

EMI 48 is an inhibitor of mutant EGFR; it inhibits L858R/T970M/C797S mutants and ex19del/T790M/C797S triple mutants (inhibitory effects at 5 μM) but has no effect on wild-type EGFR. EMI 48 induces EGFR degradation (<5 μM), and inhibits activation of ERK, S6 and AKT.

Technical Data for EMI 48

M. Wt 348.4
Formula C21H20N2O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 34564-13-1
PubChem ID 15538560
Smiles CCN(C1=CC=C2C=C(C(OC2=C1)=O)C3=NC4=C(C=CC(C)=C4)O3)CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for EMI 48

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 6.97 20 with gentle warming

Preparing Stock Solutions for EMI 48

The following data is based on the product molecular weight 348.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 14.35 mL 71.76 mL 143.51 mL
1 mM 2.87 mL 14.35 mL 28.7 mL
2 mM 1.44 mL 7.18 mL 14.35 mL
10 mM 0.29 mL 1.44 mL 2.87 mL

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References for EMI 48

References are publications that support the biological activity of the product.

Saraon et al (2020) A drug discovery platform to identify compounds that inhibit EGFR triple mutants. Nat.Chem.Biol. 16 577 PMID: 32094923

If you know of a relevant reference for EMI 48, please let us know.

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Citations for EMI 48

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.