Selective 5-HT6 agonist (with a Ki value of 16 nM at human 5-HT6 receptors). Exhibits potency comparable to serotonin for the activation of adenylate cyclase. Displays antidepressant-like effects.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 336.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.97 mL||14.86 mL||29.73 mL|
|5 mM||0.59 mL||2.97 mL||5.95 mL|
|10 mM||0.3 mL||1.49 mL||2.97 mL|
|50 mM||0.06 mL||0.3 mL||0.59 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Glennon et al (2000) 2-Substituted tryptamines: Agents with selectivity for 5-HT6 serotonin receptors. J.Med.Chem. 43 1011 PMID: 10715164
Svenningsson et al (2007) Biochemical and behavioral evidence for antidepressant-like effects of 5-HT6 receptor stimulation. J.Neurosci. 27 4201 PMID: 17428998
If you know of a relevant reference for EMDT oxalate, please let us know.
View Related Products by Product Action
Keywords: EMDT oxalate, supplier, EMDT, oxalate, 5ht6, 5-HT6, agonist, agonists, serotonin-6, 5-HT6, Receptors, 5-HT6, Receptors, Tocris Bioscience
Citations for EMDT oxalate
Citations are publications that use Tocris products.
Currently there are no citations for EMDT oxalate. Do you know of a great paper that uses EMDT oxalate from Tocris? If so please let us know.
Literature in this Area
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.