Biological Activity
High affinity apelin receptor agonist. Binds apelin receptors in left ventricle from normal and pulmonary arterial hypertensive (PAH) hearts (pKi values are 9.31 and 9.46, respectively). Bioactive fragment of ELA-32 (Cat. No. 6291). Inhibits forskolin-induced cAMP production and stimulates β-arrestin recruitment in vitro.
Technical Data
M. Wt | 2587.12 |
Formula | C112H184N40O25S3 |
Sequence |
LRKHNCLQRRCMPLHSRVPFP (Modifications: Disulfide bridge: 6-11) |
Storage | Store at -20°C |
Smiles | [H]N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC1=O)C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N1CCC[C@H]1C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
Solubility | Soluble to 2 mg/ml in water |
Product Datasheets
References
References are publications that support the biological activity of the product.
Yang et al (2017) Elabela/Toddler is an endogenous agonist of the apelin APJ receptor in the adult cardiovascular system, and exogenous administration of the peptide compensates for the downregulation of its expression in pulmonary arterial hypertension. Circulation 135 1160 PMID: 28137936
Deng et al (2015) Apela regulates fluid homeostasis by binding to the APJ receptor to activate Gi signaling. J.Biol.Chem. 290 18261 PMID: 25995451
If you know of a relevant reference for ELA-21 (human), please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: ELA-21 (human), ELA-21 (human) supplier, ELA21, Apela-21, high, affinity, apelin, receptors, agonists, agonism, APL, elabela, fragment, Apelin, Receptors, 6697, Tocris Bioscience
Citations for ELA-21 (human)
Citations are publications that use Tocris products.
Currently there are no citations for ELA-21 (human). Do you know of a great paper that uses ELA-21 (human) from Tocris? Please let us know.
Reviews for ELA-21 (human)
There are currently no reviews for this product. Be the first to review ELA-21 (human) and earn rewards!
Have you used ELA-21 (human)?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image