ELA-14 (human)

Discontinued Product

ELA-14 (human) (Cat. No. 6293) has been withdrawn from sale for commercial reasons.
Description: Potent apelin agonist; bioactive fragment of ELA-32 (Cat. No. 6291)
Alternative Names: ELA (19-32) (human),ELABELA
Datasheet
Citations
Reviews

Biological Activity for ELA-14 (human)

ELA-14 (human) is a potent apelin (APJ) receptor agonist (Ki = 0.93 nM). Bioactive fragment of ELA-32 (Cat. No. 6291). Activates Gαi1 pathway and β-arrestin-2 recruitment. Reduces arterial pressure in rat hearts. Active in vivo.

ELA-14 negative control (Cat.No. 6294) also available.

Licensing Information

Sold under agreement from the Agency for Science, Technology and Research (A*STAR), ETPL, and affiliates including the Institute of Medical Biology.

Technical Data for ELA-14 (human)

M. Wt 1707.03
Formula C75H119N25O17S2
Sequence XRRCMPLHSRVPFP

(Modifications: X = Glp)

Storage Store at -20°C
CAS Number 1886973-05-2
PubChem ID 127043902
InChI Key LKYSPGTYQNANFL-GYVBEWGNSA-N
Smiles CSCC[C@H](NC(=O)[C@H](CS)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N1CCC[C@H]1C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for ELA-14 (human)

References for ELA-14 (human)

References are publications that support the biological activity of the product.

Murza et al (2016) Discovery and structure-activity relationship of a bioactive fragment of ELABELA that modulates vascular and cardiac functions. J.Med.Chem. 59 2962 PMID: 26986036

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Keywords: ELA-14 (human), ELA-14 (human) supplier, Apelin, receptor, agonist, agonism, APJ, ELABELA, analog, beta-arrestin-2, b-arrestin-2, β-arrestin-2, Gail, Galphail, Gαil, blood, pressure, active, in, vivo, ELA, (19-32), (human), Receptors, 6293, Tocris Bioscience

Citations for ELA-14 (human)

Citations are publications that use Tocris products.

Currently there are no citations for ELA-14 (human).

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