Potent apelin (APJ) receptor agonist (Ki = 0.93 nM). ELABELA analog. Activates Gαi1 pathway and β-arrestin-2 recruitment. Reduces arterial pressure in rat hearts. Active in vivo. ELA-14 negative control (Cat.No. 6294) available.
Sold under agreement from the Agency for Science, Technology and Research (A*STAR), ETPL, and affiliates including the Institute of Medical Biology.
(Modifications: X = Glp)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 1 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 1707.03. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.59 mL||2.93 mL||5.86 mL|
|5 mM||0.12 mL||0.59 mL||1.17 mL|
|10 mM||0.06 mL||0.29 mL||0.59 mL|
|50 mM||0.01 mL||0.06 mL||0.12 mL|
References are publications that support the products' biological activity.
Murza et al (2016) Discovery and structure-activity relationship of a bioactive fragment of ELABELA that modulates vascular and cardiac functions. J.Med.Chem. 59 2962 PMID: 26986036
If you know of a relevant reference for ELA-14 (human), please let us know.
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Keywords: ELA-14 (human), supplier, Apelin, receptor, agonist, agonism, APJ, ELABELA, analog, beta-arrestin-2, b-arrestin-2, β-arrestin-2, Gail, Galphail, Gαil, blood, pressure, active, in, vivo, ELA, (19-32), (human), ELABELA, Apelin, Receptors, Apelin, Receptors, Tocris Bioscience
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