Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewELA-14 (human)
Description: Potent apelin agonist; bioactive fragment of ELA-32 (Cat. No. 6291)
Alternative Names: ELA (19-32) (human),ELABELA
Biological Activity for ELA-14 (human)
ELA-14 (human) is a potent apelin (APJ) receptor agonist (Ki = 0.93 nM). Bioactive fragment of ELA-32 (Cat. No. 6291). Activates Gαi1 pathway and β-arrestin-2 recruitment. Reduces arterial pressure in rat hearts. Active in vivo.
ELA-14 negative control (Cat.No. 6294) also available.
Licensing Information
Sold under agreement from the Agency for Science, Technology and Research (A*STAR), ETPL, and affiliates including the Institute of Medical Biology.
Technical Data for ELA-14 (human)
| M. Wt | 1707.03 |
| Formula | C75H119N25O17S2 |
| Sequence |
XRRCMPLHSRVPFP (Modifications: X = Glp) |
| Storage | Store at -20°C |
| CAS Number | 1886973-05-2 |
| PubChem ID | 127043902 |
| InChI Key | LKYSPGTYQNANFL-GYVBEWGNSA-N |
| Smiles | CSCC[C@H](NC(=O)[C@H](CS)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N1CCC[C@H]1C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for ELA-14 (human)
References for ELA-14 (human)
References are publications that support the biological activity of the product.
Murza et al (2016) Discovery and structure-activity relationship of a bioactive fragment of ELABELA that modulates vascular and cardiac functions. J.Med.Chem. 59 2962 PMID: 26986036
View Related Products by Target
View Related Products by Product Action
Keywords: ELA-14 (human), ELA-14 (human) supplier, Apelin, receptor, agonist, agonism, APJ, ELABELA, analog, beta-arrestin-2, b-arrestin-2, β-arrestin-2, Gail, Galphail, Gαil, blood, pressure, active, in, vivo, ELA, (19-32), (human), Receptors, 6293, Tocris Bioscience
Citations for ELA-14 (human)
Citations are publications that use Tocris products.
Currently there are no citations for ELA-14 (human).
Reviews for ELA-14 (human)
There are currently no reviews for this product. Be the first to review ELA-14 (human) and earn rewards!
Have you used ELA-14 (human)?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image