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Discontinued ProductELA-11 (human) (Cat. No. 6698) has been withdrawn from sale for commercial reasons.
High affinity apelin receptor agonist (Ki = 14 nM). Bioactive fragment of ELA-32 (Cat. No. 6291). Inhibits forskolin-induced cAMP production and stimulates β-arrestin recruitment in vitro.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Yang et al (2017) Elabela/Toddler is an endogenous agonist of the apelin APJ receptor in the adult cardiovascular system, and exogenous administration of the peptide compensates for the downregulation of its expression in pulmonary arterial hypertension. Circulation 135 1160 PMID: 28137936
Murza et al (2016) Discovery and structure-activity relationship of a bioactive fragment of ELABELA that modulates vascular and cardiac functions. J.Med.Chem. 59 2962 PMID: 26986036
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Keywords: ELA-11 (human), ELA-11 (human) supplier, high, affinity, apelin, APJ, receptor, agonists, agonism, Elabela, fragment, Apelin, Receptors, 6698, Tocris Bioscience
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