Potent, selective and reversible inhibitor of isoform II NO synthase (IC50 = 13 nM; approximately 20- and 30-fold selective over isoforms I and III respectively).
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 185.08. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||5.4 mL||27.02 mL||54.03 mL|
|5 mM||1.08 mL||5.4 mL||10.81 mL|
|10 mM||0.54 mL||2.7 mL||5.4 mL|
|50 mM||0.11 mL||0.54 mL||1.08 mL|
References are publications that support the products' biological activity.
Garvey et al (1994) Potent and selective inhibition of human nitric oxide synthase. J.Biol.Chem. 269 26669 PMID: 7523409
Nakane et al (1995) Novel potent and selective inhibitors of inducible nitric oxide synthase. Mol.Pharmacol. 47 831 PMID: 7536889
Squadrito et al (1996) Effects of S-ethylisothiourea, a potent inhibitor of nitirc oxide synthase, alone or in combination with a nitric oxide donor in splanchnic artery occlusion shock. Br.J.Pharmacol. 119 23 PMID: 8872352
If you know of a relevant reference for EIT hydrobromide, please let us know.
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Keywords: EIT hydrobromide, supplier, Selective, iNOS, inhibitors, inhibits, arginine, binding, site, Nitric, Oxide, Signaling, Signalling, Inducible, NO, Synthases, iNOS, iNOS, Tocris Bioscience
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