EIT hydrobromide

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Cat.No. 0873 - EIT hydrobromide | C3H8N2S.HBr | CAS No. 1071-37-0
Description: Selective iNOS inhibitor, acts arginine binding site
Chemical Name: (S)-Ethylisothiourea hydrobromide
Datasheet
Citations
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Literature

Biological Activity

Potent, selective and reversible inhibitor of isoform II NO synthase (IC50 = 13 nM; approximately 20- and 30-fold selective over isoforms I and III respectively).

Technical Data

M. Wt 185.08
Formula C3H8N2S.HBr
Storage Store at RT
CAS Number 1071-37-0
PubChem ID 200213
InChI Key SWXXKWPYNMZFTE-UHFFFAOYSA-N
Smiles NC(SCC)=N.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 18.51 100

Preparing Stock Solutions

The following data is based on the product molecular weight 185.08. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.4 mL 27.02 mL 54.03 mL
5 mM 1.08 mL 5.4 mL 10.81 mL
10 mM 0.54 mL 2.7 mL 5.4 mL
50 mM 0.11 mL 0.54 mL 1.08 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets

Certificate of Analysis is currently unavailable
on-line. Please contact Customer Service
Safety Datasheet

References

References are publications that support the products' biological activity.

Garvey et al (1994) Potent and selective inhibition of human nitric oxide synthase. J.Biol.Chem. 269 26669 PMID: 7523409

Nakane et al (1995) Novel potent and selective inhibitors of inducible nitric oxide synthase. Mol.Pharmacol. 47 831 PMID: 7536889

Squadrito et al (1996) Effects of S-ethylisothiourea, a potent inhibitor of nitirc oxide synthase, alone or in combination with a nitric oxide donor in splanchnic artery occlusion shock. Br.J.Pharmacol. 119 23 PMID: 8872352


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Keywords: EIT hydrobromide, supplier, Selective, iNOS, inhibitors, inhibits, arginine, binding, site, Nitric, Oxide, Signaling, Signalling, Inducible, NO, Synthases, iNOS, iNOS, Tocris Bioscience

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