EIT hydrobromide

Discontinued Product

EIT hydrobromide (Cat. No. 0873) has been withdrawn from sale for commercial reasons.
Cat.No. 0873 - EIT hydrobromide | C3H8N2S.HBr | CAS No. 1071-37-0
Description: Selective iNOS inhibitor, acts arginine binding site
Chemical Name: (S)-Ethylisothiourea hydrobromide
Datasheet
Citations
Reviews
Literature (3)

Biological Activity

Potent, selective and reversible inhibitor of isoform II NO synthase (IC50 = 13 nM; approximately 20- and 30-fold selective over isoforms I and III respectively).

Technical Data

M. Wt 185.08
Formula C3H8N2S.HBr
Storage Store at RT
CAS Number 1071-37-0
PubChem ID 200213
InChI Key SWXXKWPYNMZFTE-UHFFFAOYSA-N
Smiles NC(SCC)=N.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Certificate of Analysis is currently unavailable on-line.
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References

References are publications that support the biological activity of the product.

Garvey et al (1994) Potent and selective inhibition of human nitric oxide synthase. J.Biol.Chem. 269 26669 PMID: 7523409

Nakane et al (1995) Novel potent and selective inhibitors of inducible nitric oxide synthase. Mol.Pharmacol. 47 831 PMID: 7536889

Squadrito et al (1996) Effects of S-ethylisothiourea, a potent inhibitor of nitirc oxide synthase, alone or in combination with a nitric oxide donor in splanchnic artery occlusion shock. Br.J.Pharmacol. 119 23 PMID: 8872352

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Keywords: EIT hydrobromide, EIT hydrobromide supplier, Selective, iNOS, inhibitors, inhibits, arginine, binding, site, Nitric, Oxide, Signaling, Signalling, Inducible, NO, Synthases, 0873, Tocris Bioscience

Citations for EIT hydrobromide

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