(E)-4-Hydroxy-4-(4-nitrophenyl)-2-butenoic acid

Discontinued Product

Unfortunately (E)-4-Hydroxy-4-(4-nitrophenyl)-2-butenoic acid (Cat. No. 0539) has been withdrawn from sale for commercial reasons.
Cat.No. 0539 - (E)-4-Hydroxy-4-(4-nitrophenyl)-2-butenoic acid
Description: GHB receptor ligand
Chemical Name: trans-4-hydroxy-4-(4-nitrophenyl)crotonic acid

Biological Activity

The most potent of a series of analogues at binding to the γ-hydroxybutyric acid (GHB) receptor and for inhibition of dopamine release (18-fold more potent than GHB).

Technical Data

M. Wt 223.19
Storage Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 223.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.48 mL 22.4 mL 44.8 mL
5 mM 0.9 mL 4.48 mL 8.96 mL
10 mM 0.45 mL 2.24 mL 4.48 mL
50 mM 0.09 mL 0.45 mL 0.9 mL

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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Product Datasheets

Certificate of Analysis is currently unavailable
on-line. Please contact Customer Service
Safety Datasheet


References are publications that support the products' biological activity.

Hechler et al (1993) γ-hydroxybutyrate ligands possess antidopaminergic and neuroleptic-like activities. J.Pharmacol.Exp.Ther. 264 1406 PMID: 8095552

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Keywords: (E)-4-Hydroxy-4-(4-nitrophenyl)-2-butenoic acid, supplier, Miscellaneous, GABA, GABAB, Receptors, Miscellaneous, GABA, Tocris Bioscience

Citations for (E)-4-Hydroxy-4-(4-nitrophenyl)-2-butenoic acid

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

GABA Receptors

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.