dTAGV-1 hydrochloride

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Description: Hydrochloride salt of dTAGV-1 (Cat. No. 6914); suitable for in vivo use
Chemical Name: (R)-3-(3,4-Dimethoxyphenyl)-1-(2-(2-((7-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-7-oxoheptyl)amino)-2-oxoethoxy)phenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate hydrochloride
Purity: ≥98% (HPLC)
Reviews (1)
Literature (3)

Biological Activity for dTAGV-1 hydrochloride

dTAGV-1 hydrochloride is a hydrochloride salt of dTAGV-1 (Cat. No. 6914). Suitable for use in vivo. Following ip administration of 10 mg/kg in mice: T½ = 4.43 h; Cmax = 2123 ng mL-1; AUCinf = 18517 hr*ng mL-1 and CL = 9.05 mL min-1 kg-1

Negative control dTAGV-1-NEG (Cat. No. 6915) also available.

Important: It is recommended that DMSO stock solutions of this compound are made and used on the same day and are not subjected to freeze/thaw.

Licensing Information

Sold under license from Dana-Farber Cancer Institute

Technical Data for dTAGV-1 hydrochloride

M. Wt 1284.01
Formula C68H90N6O14S.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2624313-16-0
Smiles C[C@H](NC([C@@H]1C[C@@H](O)CN1C([C@@H](NC(CCCCCCNC(COC2=CC=CC=C2[C@H](OC([C@@H]3CCCCN3C([C@@H](CC)C4=CC(OC)=C(OC)C(OC)=C4)=O)=O)CCC5=CC(OC)=C(OC)C=C5)=O)=O)C(C)(C)C)=O)=O)C6=CC=C(C=C6)C7=C(N=CS7)C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for dTAGV-1 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 128.4 100

Preparing Stock Solutions for dTAGV-1 hydrochloride

The following data is based on the product molecular weight 1284.01. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.78 mL 3.89 mL 7.79 mL
5 mM 0.16 mL 0.78 mL 1.56 mL
10 mM 0.08 mL 0.39 mL 0.78 mL
50 mM 0.02 mL 0.08 mL 0.16 mL

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Product Datasheets for dTAGV-1 hydrochloride

References for dTAGV-1 hydrochloride

References are publications that support the biological activity of the product.

Nabet et al (2020) Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules. Nat.Commun. 11 4687 PMID: 32948771

Abuhashem et al (2022) Generation of knock-in degron tags for endogenous proteins in mice using the dTAG system. STAR Protoc. 3 101660 PMID: 36097386

If you know of a relevant reference for dTAGV-1 hydrochloride, please let us know.

Keywords: dTAGV-1 hydrochloride, dTAGV-1 hydrochloride supplier, dTAGVHL1, hydrochloride, salt, HCl, degraders, degrades, targeted, protein, degradation, FKBP12F36V, fusion, mutant, PROTAC, VHL, von, Hippel, Lindau, TPD, in, vivo, active, TAG, Degradation, Platform, 7374, Tocris Bioscience

Citations for dTAGV-1 hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for dTAGV-1 hydrochloride. Do you know of a great paper that uses dTAGV-1 hydrochloride from Tocris? Please let us know.

Reviews for dTAGV-1 hydrochloride

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Degradation of Myc fusion protein.
By Bikesh Nirala on 06/21/2022
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Osteosarcoma cell lines

I used dTAG-v1 for in-vivo and in-vitro protein degradation and it worked perfectly.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Targeted Protein Degradation Research Product Guide

Targeted Protein Degradation Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support Targeted Protein Degradation research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Ubiquitin-Proteasome System Proteins
  • Assays for Protein Degradation
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia

Validating Targets for TPD Using dTAG Poster

Validating Targets for TPD Using dTAG Poster

The dTAG platform offers a generalizable strategy to degrade, in principle, any intracellular protein of interest (POI) and is a useful strategy for exploration and validation of targets. This poster presents a workflow solution for target validation, from custom TAG knock-in cell-lines for your POI, different dTAG Degraders to knockdown you POI, to automated assays for protein degradation using Simple WesternTM instruments. Data are also presented on the use of an antibody that recognizes the TAG domain (FKBP12F36V) for detection of degradation. Presented at TPD Europe, March 2022, London, UK.