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Biological Activity for dTAGV-1-NEG
dTAGV-1-NEG is a negative control for dTAGV-1 (Cat. No. 6914).
Sold under license from Dana-Farber Cancer Institute
Technical Data for dTAGV-1-NEG
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for dTAGV-1-NEG
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for dTAGV-1-NEG
The following data is based on the product molecular weight 1247.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.8 mL||4.01 mL||8.02 mL|
|5 mM||0.16 mL||0.8 mL||1.6 mL|
|10 mM||0.08 mL||0.4 mL||0.8 mL|
|50 mM||0.02 mL||0.08 mL||0.16 mL|
References for dTAGV-1-NEG
References are publications that support the biological activity of the product.
Nabet et al (2020) Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules. Nat.Commun. 11 4687 PMID: 32948771
If you know of a relevant reference for dTAGV-1-NEG, please let us know.
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Keywords: dTAGV-1-NEG, dTAGV-1-NEG supplier, dTAGv1, negative, control, TAG, degraders, degrades, degradation, FKBP12F36V, fusion, protein, mutant, PROTAC, VHL, von, Hippel, Lindau, controls, Degradation, Platform, 6915, Tocris Bioscience
Citations for dTAGV-1-NEG
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Targeted Protein Degradation Research Product GuideUpdated
This brochure highlights the tools and services available from Bio-Techne to support Targeted Protein Degradation research, including:
- Active Degraders
- TAG Degradation Platform
- Degrader Building Blocks
- Ubiquitin-Proteasome System Proteins
- Assays for Protein Degradation
Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia