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Biological Activity for DSRM-3716
DSRM-3716 is a potent, reversible inhibitor of SARM1 NAD(+) hydrolase (IC50 = 75 nM), which displays selectivity for SARM1 over related enzymes NAMPT and NMNAT and a panel of receptors and transporters. In vitro, DSRM-3716 decreases cyclic adenosine diphosphate ribose (cADPR) levels in mouse dorsal root ganglia (DRG) neurons, and protects mouse DRG and iPSC-derived human motor neurons against axonal degeneration. In axons with rotenone (Cat. No. 3616)-induced mitochondrial injury, DSRM-3716 rescues axons displaying indicators of degeneration.
Technical Data for DSRM-3716
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for DSRM-3716
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for DSRM-3716
The following data is based on the product molecular weight 255.06. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.92 mL||19.6 mL||39.21 mL|
|5 mM||0.78 mL||3.92 mL||7.84 mL|
|10 mM||0.39 mL||1.96 mL||3.92 mL|
|50 mM||0.08 mL||0.39 mL||0.78 mL|
References for DSRM-3716
References are publications that support the biological activity of the product.
O Hughes et al (2021) Small molecules SARM1 inhibitors recapitulate the SARM1-/- phenotype and allow recovery of a metastable pool of axons fated to degenerate. Cell Rep. 34 PMID: 33406435
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Keywords: DSRM-3716, DSRM-3716 supplier, SARM1, NAD, hydrolase, inhibitor, inhibits, inhibitors, axonal, degeneration, toll-like, receptor, signaling, ADPR, Other, Hydrolases, Toll-like, Receptors, 7414, Tocris Bioscience
Citations for DSRM-3716
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