DSRM-3716

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Cat.No. 7414 - DSRM-3716 | C9H6IN | CAS No. 58142-99-7
Description: Potent and reversible SARM1 NAD hydrolase inhibitor
Chemical Name: 5-Iodoisoquinoline
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews

Biological Activity for DSRM-3716

DSRM-3716 is a potent, reversible inhibitor of SARM1 NAD(+) hydrolase (IC50 = 75 nM), which displays selectivity for SARM1 over related enzymes NAMPT and NMNAT and a panel of receptors and transporters. In vitro, DSRM-3716 decreases cyclic adenosine diphosphate ribose (cADPR) levels in mouse dorsal root ganglia (DRG) neurons, and protects mouse DRG and iPSC-derived human motor neurons against axonal degeneration. In axons with rotenone (Cat. No. 3616)-induced mitochondrial injury, DSRM-3716 rescues axons displaying indicators of degeneration.

Technical Data for DSRM-3716

M. Wt 255.06
Formula C9H6IN
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 58142-99-7
PubChem ID 11391181
InChI Key CUILFTFMBBGSFT-UHFFFAOYSA-N
Smiles IC1=CC=CC=2C=NC=CC12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DSRM-3716

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 25.51 100
DMSO 25.51 100

Preparing Stock Solutions for DSRM-3716

The following data is based on the product molecular weight 255.06. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.92 mL 19.6 mL 39.21 mL
5 mM 0.78 mL 3.92 mL 7.84 mL
10 mM 0.39 mL 1.96 mL 3.92 mL
50 mM 0.08 mL 0.39 mL 0.78 mL

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References for DSRM-3716

References are publications that support the biological activity of the product.

O Hughes et al (2021) Small molecules SARM1 inhibitors recapitulate the SARM1-/- phenotype and allow recovery of a metastable pool of axons fated to degenerate. Cell Rep. 34 PMID: 33406435


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Keywords: DSRM-3716, DSRM-3716 supplier, SARM1, NAD, hydrolase, inhibitor, inhibits, inhibitors, axonal, degeneration, toll-like, receptor, signaling, ADPR, Other, Hydrolases, Toll-like, Receptors, 7414, Tocris Bioscience

Citations for DSRM-3716

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