Potent TLR7 agonist (EC50 = 7.2 nM). Activates several immune effector cells in vitro. Suppresses metastasis in vivo and enhances efficacy of radiation therapy in a model of colorectal carcinoma.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 400.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.5 mL||12.49 mL||24.97 mL|
|5 mM||0.5 mL||2.5 mL||4.99 mL|
|10 mM||0.25 mL||1.25 mL||2.5 mL|
|50 mM||0.05 mL||0.25 mL||0.5 mL|
References are publications that support the biological activity of the product.
Adlard et al (2014) A novel systemically administered Toll-like receptor 7 agonist potentiates the effect of ionizing radiation in murine solid tumor models. Int.J.Cancer 135 820 PMID: 24390981
Nakamura et al (2013) Synthesis and evaluation of 8-oxoadenine derivatives as potent Toll-like receptor 7 agonists with high water solubility. Bioorg.Med.Chem.Lett. 23 669 PMID: 23265901
If you know of a relevant reference for DSR 6434, please let us know.
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Keywords: DSR 6434, DSR 6434 supplier, DSR6434, Potent, TLR7, agonists, agonism, toll-like, receptors, antitumour, antitumor, Toll-like, Receptors, 4809, Tocris Bioscience
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