DREADD agonist 21 dihydrochloride

Pricing Availability   Qty
Cat.No. 6422 - DREADD agonist 21 dihydrochloride | C17H18N4.2HCl
Description: Potent muscarinic DREADD agonist; water soluble version of DREADD agonist 21 (Cat. No. 5548)
Chemical Name: 11-(1-Piperazinyl)-5H-dibenzo[b,e][1,4]diazepine dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Water soluble version of DREADD agonist 21 (Cat. No. 5548). Potent muscarinic DREADD agonist.

Technical Data

M. Wt 351.27
Formula C17H18N4.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
Smiles C1(N2CCNCC2)=NC(C=CC=C3)=C3NC4=C1C=CC=C4.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 35.13 100
DMSO 35.13 100

Preparing Stock Solutions

The following data is based on the product molecular weight 351.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.85 mL 14.23 mL 28.47 mL
5 mM 0.57 mL 2.85 mL 5.69 mL
10 mM 0.28 mL 1.42 mL 2.85 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Chen et al (2015) The first structure-activity relationship studies for designer receptors exclusively activated by designer drugs. ACS Chem.Neurosci. 18 476 PMID: 25587888


If you know of a relevant reference for DREADD agonist 21 dihydrochloride, please let us know.

View Related Products by Product Action

View all DREADD Ligand Activators

Keywords: DREADD agonist 21 dihydrochloride, DREADD agonist 21 dihydrochloride supplier, designer, receptors, drugs, DREADDs, hM3Dq, muscarinic, DREADD, ligands, Non-selective, Muscarinics, 6422, Tocris Bioscience

Citations for DREADD agonist 21 dihydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for DREADD agonist 21 dihydrochloride. Do you know of a great paper that uses DREADD agonist 21 dihydrochloride from Tocris? Please let us know.

Reviews for DREADD agonist 21 dihydrochloride

There are currently no reviews for this product. Be the first to review DREADD agonist 21 dihydrochloride and earn rewards!

Have you used DREADD agonist 21 dihydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Chemogenetics

Chemogenetics Research Bulletin

Produced by Tocris, the chemogenetics research bulletin provides an introduction to chemogenetic methods to manipulate neuronal activity. It outlines the development of RASSLs, DREADDs and PSAMs, and the use of chemogenetic compounds. DREADD ligands and PSEMs available from Tocris are highlighted.