DREADD agonist 21

Pricing Availability Delivery Time Qty
Cat.No. 5548 - DREADD agonist 21 | C17H18N4 | CAS No. 56296-18-5
Description: Potent hM3Dq DREADD agonist
Chemical Name: 11-(1-Piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent muscarinic hM3Dq DREADD agonist (EC50 = 1.7 nM). Highly selective for hM3Dq DREADDs over endogenous hM3 receptors.

Technical Data

M. Wt 278.35
Formula C17H18N4
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 56296-18-5
PubChem ID 11818276
InChI Key JCBYXNSOLUVGTF-UHFFFAOYSA-N
Smiles C1(N4CCNCC4)=NC(C=CC=C3)=C3NC2=C1C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 27.84 100
ethanol 27.84 100

Preparing Stock Solutions

The following data is based on the product molecular weight 278.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.59 mL 17.96 mL 35.93 mL
5 mM 0.72 mL 3.59 mL 7.19 mL
10 mM 0.36 mL 1.8 mL 3.59 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Chen et al (2015) The first structure-activity relationship studies for designer receptors exclusively activated by designer drugs. ACS Chem.Neurosci. 18 476 PMID: 25587888


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Keywords: DREADD agonist 21, supplier, designer, receptors, drugs, DREADDs, hM3Dq, muscarinic, receptors, DREADDs, Tocris Bioscience

Citations for DREADD agonist 21

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Literature in this Area

GPCR

GPCR Product Listing

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  • Frizzled Receptors
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Pathways for DREADD agonist 21

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