DREADD agonist 21

Pricing Availability Delivery Time Qty
Cat.No. 5548 - DREADD agonist 21 | C17H18N4 | CAS No. 56296-18-5
Description: Potent hM3Dq DREADD agonist
Chemical Name: 11-(1-Piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
Purity: ≥98% (HPLC)

Biological Activity

Potent muscarinic hM3Dq DREADD agonist (EC50 = 1.7 nM). Highly selective for hM3Dq DREADDs over endogenous hM3 receptors.

Technical Data

M. Wt 278.35
Formula C17H18N4
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 56296-18-5
PubChem ID 11818276
Smiles C1(N4CCNCC4)=NC(C=CC=C3)=C3NC2=C1C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 27.84 100
ethanol 27.84 100

Preparing Stock Solutions

The following data is based on the product molecular weight 278.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.59 mL 17.96 mL 35.93 mL
5 mM 0.72 mL 3.59 mL 7.19 mL
10 mM 0.36 mL 1.8 mL 3.59 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Chen et al (2015) The first structure-activity relationship studies for designer receptors exclusively activated by designer drugs. ACS Chem.Neurosci. 18 476 PMID: 25587888

If you know of a relevant reference for DREADD agonist 21, please let us know.

Keywords: DREADD agonist 21, supplier, designer, receptors, drugs, DREADDs, hM3Dq, muscarinic, receptors, DREADDs, Tocris Bioscience

Citations for DREADD agonist 21

Citations are publications that use Tocris products.

Currently there are no citations for DREADD agonist 21. Do you know of a great paper that uses DREADD agonist 21 from Tocris? If so please let us know.

Commented out for usability testing


TODO: Add Reviews

Literature in this Area


GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling

Pathways for DREADD agonist 21


TODO: Add Protocols